Dorsomorphin ≥98% (by TLC)
About this item
Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.
- AMPK inhibitor
Yellow solid.
Soluble in DMSO (3mg/ml, warm)
- CAS Number:866405-64-3
- Formula:C₂₄H₂₅N₅O
- MDL Number:MFCD08705402
- Molecular Weight:399.5 g/mol
- Storage Temperature:Freezer
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Product Details & Documents
Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.
- AMPK inhibitor
Yellow solid.
Soluble in DMSO (3mg/ml, warm)
- CAS Number:866405-64-3
- Formula:C₂₄H₂₅N₅O
- MDL Number:MFCD08705402
- Molecular Weight:399.5 g/mol
- Storage Temperature:Freezer
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