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Human Recombinant Proprotein Convertase 9 (from Cells)
Human Recombinant Proprotein Convertase 9 (from Cells)
Catalog # PRSI91-780
Supplier:  ProSci Inc.
New Product
CAS Number:  
Human Recombinant Proprotein Convertase 9 (from Cells)
Catalog # PRSI91-780
Supplier:  ProSci Inc.
New Product
CAS Number:  

Specifications

  • Pk:
    0,05 mg
  • Enzyme type:
    Recombinant
  • Source:
    Cells
  • Species:
    Human
  • Environmentally Preferable:
  • Tag sequence:
    C-6 His tag
  • Storage conditions:
    Store at −20 °C, stable for 6 months after receipt, please minimise freeze - thaw cycles
  • Endotoxin content:
    <0,1 ng/µg (1 IEU/µg) as determined by LAL test
  • Enzyme name:
    Proprotein Convertase 9
  • Enzyme synonyms:
    Proprotein Convertase Subtilisin/Kexin Type 9, Neural Apoptosis-Regulated Convertase 1, NARC-1, Proprotein Convertase 9, PC9, Subtilisin/Kexin-Like Protease PC9, PCSK9, NARC1
  • Purity:
    >95% as determined by reducing SDS-PAGE
  • Molecular weight:
    71,05 kD
  • Sequence:
    Gln31-Gln692
  • Formulation:
    Supplied as a 0,2 µm filtered solution of 50 mM HEPES, 150 mM NaCl, pH 7,4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilised protein in ddH₂O. Please aliquot the reconstituted solution to minimise freeze-thaw cycles.
  • Tested applications:
    Bioassay

Specifications

About this item

Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily.

This recombinant protein can be used for biological assays. For research use only.

Fusion-Tag: C-6 His tag

PCSK9 is synthesised as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.