An Sandwich ELISA kit to quantify human ER-alpha in human serum, plasma and other biological fluids.

• Easy, convenient and time-saving method to measure the level of ER-alpha in human serum, plasma, tissue homogenates, culture supernatants and other biological fluids
• Detection Range: 62,5 to 4000 pg/ml
• Sensitivity: <37,5 pg/ml

Estrogen Receptor is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. BioVision’s ER-alpha ELISA kit is a sandwich ELISA assay for the quantitative measurement of human ER-alpha in serum, plasma and cell culture supernatants. The density of colour is proportional to the amount of human ER-alpha captured from the samples.

All products are FOR RESEARCH USE ONLY.   PRODUCTS ARE NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES.  Customer is granted a limited use non-exclusive licence for its own internal research.  Any control manufacturer supplies with a Product is limited to use only to validate the relevant Product.  By using the Product, Customers agree not to attempt to reverse engineer or otherwise perform any compositional, structural, functional or other analyses directed to learning the methodology, formulae, sequences, processes, make-up or production of any of the Products or portions thereof.