- Antibody type:Primary
- Antigen name:PDE4D
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Flow cytometry:Yes
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitope:401-550/809
- Form:Liquid
- Gene ID:5144
- Antigen synonyms:DKFZp686M11213|PDE43|cAMP specic phosphodiesterase 4D|HSPDE4D|PDE4DN2|Phosphodiesterase 4D cAMP specic phosphodiesterase E3 dunce homolog Drosophila|Phosphodiesterase E3 dunce homolog Drosophila|cAMP specic phosphodiesterase PDE4D6|cAMP specic 3' 5' cyclic phosphodiesterase 4D|cAMP specic phosphodiesterase PDE4D|STRK 1|DPDE 3|PDE 43|Phosphodiesterase 4D, cAMP specic dunce|STRK1.|cAMP specic 3',5' cyclic phosphodiesterase 4D|Phosphodiesterase 4D cAMP specic dunce Drosophila homolog phosphodiesterase E3|cyclic AMP phosphodiesterase|Phosphodiesterase 4D cAMP specic|DPDE3|Dunce like phosphodiesterase E3|FLJ97311
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:90 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human PDE4D
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins.
Type: Primary
Antigen: PDE4D
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 401-550/809
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat