The human DIO3 selenoprotein is encoded by the DIO3 gene and catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'- triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively.
We provide the human DIO3 enzyme with approx. 20% Sec contents, mixed with inactive forms containing Sec-to-Lys and Sec-to-Gln substitutions, at more than 95% purity in aliquots at amounts from 50 to 500 µg.

• Genuine Sec-containing selenoproteins
• More than 95% purity
• No animals used as protein sources (grown in bacteria)