About this item
Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter.
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- Low endotoxin
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IL-1β and the independently regulated IL-1α protein have overlapping pro-inflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.
Specifications
- Protein-Funktion:Cytokine
- Protein/Peptid-Typ:Rekombinant
- Ursprung:E. coli
- Spezies:Human
- Lagerbedingungen:−20 °C
- Biologische Aktivität:D10S cell proliferation at less than or equal to 12 pg/ml or (8,3×10⁷ units/mg specific units)
- Reconstitution instructions:Reconstitute with sterile water at 0,1 mg/ml
- Tierfrei:Y
- Proteinsynonym:EP|Catabolin|LAF|LEM|MCF
- UniProtKB:P01584
- Protein/Peptid-Name:IL-1 beta
- Purity:>95%
- Molecular weight:17.5 kDa (monomer)
- Sequence:MAPVRSLNCT LRDSQQKSLV MSGPYELKAL HLQGQDMEQQ VVFSMSFVQG EESNDKIPVA LGLKEKNLYL SCVLKDDKPT LQLESVDPKN YPKKKMEKRF VFNKIEINNK LEFESAQFPN WYISTSQAEN MPVFLGGTKG GQDITDFTMQ FVSS
- Endotoxinspiegel:≤1 EUs/μg
- Zusammensetzung:Lyophilised from a sterile (0,2 µm) filtered aqueous solution containing 10 mM sodium phosphate, pH 7,5
- Transporttemperatur:Ambient
- Validierte Anwendungen:Bioassay
- Konjugation:Unconjugated
- Endotoxingehalt:Endotoxin LAL (EU/µg) ≤1
- Gen-ID:P01584
- Frei von Endotoxinen:N
- Frei von Trägern:Y
- Frei von Proteasen:N
- Frei von Nukleasen:N
- Sorte:RUO
Specifications
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: RATIOLAB
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: Corning
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: EPPENDORF
Supplier: EPPENDORF
Supplier: LONZA