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Human recombinant Tryptophan 5-hydroxylase 2 (from E. coli)
Katalognr. PRSI92-161
Anbieter:  ProSci Inc.
CAS-Nummer:  
Human recombinant Tryptophan 5-hydroxylase 2 (from E. coli)
Katalognr. PRSI92-161
Anbieter:  ProSci Inc.
CAS-Nummer:  

Technische Daten

  • Pk:
    50 µG
  • Enzyme type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Human
  • Tag sequence:
    N-6 His tag
  • Storage conditions:
    Store at −20 °C, stable for 6 months after receipt. Please minimize freeze−thaw cycles.
  • Enzyme name:
    Tryptophan 5-Hydroxylase 2
  • Purity:
    >95% as determined by reducing SDS-PAGE
  • Molecular weight:
    58.8 kD
  • Sequence:
    Met1-Ile496
  • Formulation:
    Supplied as a 0.2 µm filtered solution of 20 mM PB,150 mM NaCl,pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested applications:
    Biological assays

Technische Daten

Über diesen Artikel

Tryptophan 5-hydroxylase 2 (TPH2) is an isozyme member of the biopterin-dependent aromatic amino acid hydroxylase family. TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression found in the raphe nucleus of the midbrain. TPH2 catalyses the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD). Defects in TPH2 are the cause of psychiatric diseases such as bipolar affective disorder and major depression.

Fusion-Tag: N-6 His tag

This recombinant protein can be used for biological assays. For research use only.