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Human recombinant Aldo-Keto Reductase 1C4 (from E. coli)
Human recombinant Aldo-Keto Reductase 1C4 (from E. coli)
Catalog # PRSI92-002
Supplier:  ProSci Inc.
CAS Number:  
Human recombinant Aldo-Keto Reductase 1C4 (from E. coli)
Catalog # PRSI92-002
Supplier:  ProSci Inc.
CAS Number:  

Specifications

  • Pk:
    50 µG
  • Enzyme type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Human
  • Tag sequence:
    N-6 His tag
  • Storage conditions:
    Store at −20 °C, stable for 6 months after receipt. Please minimize freeze−thaw cycles.
  • Enzyme name:
    Aldo-Keto Reductase 1C4
  • Purity:
    >95% as determined by reducing SDS-PAGE
  • Molecular weight:
    39.3 kD
  • Sequence:
    Met1-Tyr323
  • Formulation:
    Supplied as a 0.2 µm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested applications:
    Bioassay

Specifications

About this item

Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyses the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyses the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5- alpha-Androstan-3- alpha,17- beta -diol (3- alpha-diol). In addition, AKR1C4 also has some 20- alpha-Hydroxysteroid Dehydrogenase activity.

Fusion-Tag: N-6 His tag

This recombinant protein can be used for biological assays. For research use only.