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Human recombinant Cysteine Dioxygenase Type 1 (from E. coli)
  PRSI91-984
 :  
Human recombinant Cysteine Dioxygenase Type 1 (from E. coli)
  PRSI91-984
 :  

 

  • Pk:
    50 µG
  • Enzyme type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Human
  • Tag sequence:
    N-6 His tag
  • Storage conditions:
    Store at −20 °C, stable for 6 months after receipt. Please minimize freeze−thaw cycles.
  • Enzyme name:
    Cysteine Dioxygenase Type 1
  • Purity:
    >95% as determined by reducing SDS-PAGE
  • Molecular weight:
    25.1 kD
  • Sequence:
    Met1-Asn200
  • Formulation:
    Supplied as a 0.2 µm filtered solution of 20 mM TrisHCl, 1 mM DTT, 10% Glycerol, pH 8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested applications:
    Bioassay

 

 

Cysteine Dioxygenase Type 1 (CDO1) is a mammalian non-heme iron enzyme that belongs to the cysteine dioxygenase family. CDO1 is highly expressed in the liver and placenta, and has a low expression in heart, brain and pancreas. CDO1 can also be detected in hepatoblastoma HepG2 cells. CDO1 catalyses the conversion of L-cysteine to cysteine sulfinic acid by incorporation of dioxygen. CDO1 is a vital regulator of cellular cysteine concentrations and has an essential role in maintaining the hepatic concentration of intracellular free cysteine within a proper narrow range. CDO1 is able to alter intracellular cysteine levels and glutathione levels.

Fusion-Tag: N-6 His tag

This recombinant protein can be used for biological assays. For research use only.