Technische Daten
- Antigen name:Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-cells Inhibitor, Alpha
- Antigen symbol:NFKBIA
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:MAD3|IkappaBalpha|IkB-alpha|Major histocompatibility complex enhancer-binding protein MAD3|NFKBI|NF-kappa-B inhibitor alpha|I-kappa-B-alpha|IKBA
- Concentration:1 mg/mL
- Immunogen:IkB-a (Phospho-Tyr42) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 42 (E-E-Y (p) -E-Q) derived from Human IkappaB-β.
- Size:100 µg
- Pk:100 µG
Technische Daten
Über diesen Artikel
Inhibits the activity of dimeric NF-κ-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type:
Antigen: NFKBIA
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat