- Antibody type:Primary
- Antigen name:Tripartite Motif-containing 3
- Antigen symbol:TRIM3
- Clonality:Polyclonal
- Conjugation:Cy3®
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Environmentally Preferable:
- Cross adsorption:No
- Form:liquid
- Gene ID:10612
- Antigen synonyms:σ-actinin-4 interacts with the RBCC domain of TRIM3|also known as RING finger protein 22 RNF22|RING finger protein 97 RNF97 or brain-expressed RING finger protein BERP|two proteins associated with the actin cytoskeleton. Specically|also known as the RING-B-box coiled-coil RBCC family. Members of the RBCC family have an N-terminal RING finger|RNF9,Tripartite mot-containing protein 3 TRIM3|TRIM3 has been shown to interact with σ-actinin-4 and myosin V|a leucine coiled-coil region and a variable C-terminal domain. Localized to cytoplasmic filaments|followed by one or two zinc-binding domains B-box domains|is a 744 amino acid member of the TRIM family|and the C-terminal tail of Myosin V interacts with with the unique C-terminal Γê½-propeller domain of TRIM3. These associations suggest that TRIM3 may play a role in cell motility and cargo transport. Three named isoforms of TRIM3 exist as a result of alternative splicing events.
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at –20 °C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Pk:100 µl
Tripartite motif-containing protein 3 (TRIM3), also known as RING finger protein 22 (RNF22), RING finger protein 97 (RNF97) or brain-expressed RING finger protein (BERP), is a 744 amino acid member of the TRIM family, also known as the RING-B-box coiled-coil (RBCC) family. Members of the RBCC family have an N-terminal RING finger, followed by one or two zinc-binding domains (B-box domains), a leucine coiled-coil region and a variable C-terminal domain. Localized to cytoplasmic filaments, TRIM3 has been shown to interact with å-actinin-4 and myosin V, two proteins associated with the actin cytoskeleton. Specifically, å-actinin-4 interacts with the RBCC domain of TRIM3, and the C-terminal tail of Myosin V interacts with with the unique C-terminal ∫-propeller domain of TRIM3. These associations suggest that TRIM3 may play a role in cell motility and cargo transport. Three named isoforms of TRIM3 exist as a result of alternative splicing events.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: TRIM3
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat