This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Type: Primary
Antigen: TYMS
Clonality: Monoclonal
Clone: TMS715
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
- Catalog No:
- BNC880715-100
- BNC880715-500
- Antigen symbol:
- TYMS
- TYMS
- Antigen name:
- Thymidylate Synthase
- Thymidylate Synthase
- Antigen synonyms:
- TSase|TS|TMS|Tyms thymidylate synthetase|dTMP synthase|TYMS protein
- TSase|TS|TMS|Tyms thymidylate synthetase|dTMP synthase|TYMS protein
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 488A
- CF® 488A
- Clone:
- Clone TMS715
- Clone TMS715
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 369762
- 369762
- Isotype:
- IgG1 kappa
- IgG1 kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
: VWR Chemicals
: VWR Chemicals
: VWR Collection
: VWR Collection
: VWR Collection
: VWR Collection
: KIMBERLY CLARK
: VWR Collection