About this item
Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Type: Primary
Antigen: CCND1
Clonality: Monoclonal
Clone: DCS-6
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human, Monkey, Mouse, Rat
Specifications
- Catalog No:
- BNC400007-500
- BNC400007-100
- Antigen symbol:
- CCND1
- CCND1
- Antigen name:
- Cyclin D1
- Cyclin D1
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 640R
- CF® 640R
- Clone:
- Clone DCS-6
- Clone DCS-6
- Reactivity:
- Monkey, Human, Rat, Mouse
- Monkey, Human, Rat, Mouse
- Host:
- Mouse
- Mouse
- Gene ID:
- 523852 , 667996
- 523852 , 667996
- Isotype:
- IgG2a kappa
- IgG2a kappa
- Western blot:
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Supplier: VWR Chemicals
Supplier: VWR Chemicals
Supplier: KIMBERLY CLARK
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Chemicals
Supplier: VWR Collection
Supplier: Merck
Supplier: HEATHROW
Supplier: VWR Chemicals
Supplier: VWR Collection
Supplier: VWR Collection