The members of the Src-family kinases are Src, Lyn, Fyn, Yes, Hck, Lck, Fgr, Blk, and Yrk. Each of these have a common structure consisting of an unique domain at the N-terminal, followed by SH3, SH2 and tyrosine kinase domains.
In immume cells, the Src-family kinases play roles as critical regulators of a large number of intracellular signaling pathways, including integrin signaling pathway. Integrins are major cellular receptor that mediate cell to cell and cell to substratum interactions.
Lck is expressed almost exclusively in T cells and interacts with cytoplasmic regions of CD4 and CD8 coreceptor molecules, and thus plays an important role in relaying TCR-mediated activation signal. Lck is
regulated by phosphorylation of its Tyr394 and Tyr505.

Western Blot: 1:1,000; Immunoprecipitation: 2 ?l;

Type: Primary
Antigen: LCK (lymphocyte-specific protein tyrosine kinase)
Clonality: Monoclonal
Clone: AF4D5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human