Anti-ANKLE2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog # BOSSBS-9743R-A750

Supplier: Bioss

Catalog # BOSSBS-9743R-A750

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
ANKLE2
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 750
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Western blot:
Yes
Epitope:
251-350/938
Form:
Liquid
Gene ID:
23141
Antigen synonyms:
LEM domain containing 7|ANKLE2|ANKL2_HUMAN|ANKLE 2|LEMD 7|Ankyrin repeat and LEM domain-containing protein 2|LEMD7|ankyrin repeat and LEM domain containing 2
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
104 kDa
Storage temperature:
Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human ANKLE2
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Specifications

About this item

Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKLE2 (ankyrin repeat and LEM domain containing 2), also known as LEMD7, is a 938 amino acid single-pass membrane protein containing an ANK repeat and a LEM domain. Existing as two isoforms produced by alternative splicing events, the gene encoding ANKLE2 maps to human chromosome 12, which encodes over 1100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

Type: Primary
Antigen: ANKLE2
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 251-350/938
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat