Specifications
- Antibody type:Primary
- Antigen name:hydrogen exchanger 3
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Western blot:Yes
- Epitope:301-400/834
- Form:Liquid
- Antigen synonyms:MGC126720|Solute carrier family 9 sodium/hydrogen exchanger, isoform 3|NHE3|Solute carrier family 9 member 3|SLC9A 3|Slc9a3|MGC126718|Solute carrier family 9 sodium/hydrogen exchanger, member 3|Sodium/hydrogen exchanger, apical epithelial|NHE-3|Sodium/hydrogen exchanger 3|SL9A3_HUMAN|NHE 3|Na+/H+ exchanger 3|Sodium
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:93 kDa
- Storage temperature:Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human NHE3
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localises to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells.
Type: Primary
Antigen: hydrogen exchanger 3
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 301-400/834
Host: Rabbit
Isotype: IgG
Reactivity: