Anti-RNF75 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog # BOSSBS-8391R-A680

Supplier: Bioss

Catalog # BOSSBS-8391R-A680

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
RNF75
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 680
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Human,
Mouse
Western blot:
Yes
Environmentally Preferable:
Epitope:
1-70/108
Form:
Liquid
Gene ID:
9978
Antigen synonyms:
ROC 1|RNF 75|RING finger protein 75|Ringbox protein 1|MGC1481|Regulator of Cullins 1|E3 ubiquitin-protein ligase RBX1|RNF75|Rbx1|MGC13357|Rbx 1|RING-box protein 1|RING finger protein|RING box protein 1|Protein ZYP|Ring box 1|RBX1_HUMAN|ZYP protein
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
12 kDa
Storage temperature:
Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human ROC1/RNF75
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Specifications

About this item

E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.

Type: Primary
Antigen: RNF75
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 1-70/108
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse