Specifications
- Antibody type:Primary
- Antigen name:CASK
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Rat
- Epitope:651-750/926
- Form:Liquid
- Antigen synonyms:Protein lin-2 homolog|CMG|Lin 2 homolog|Pals3|TNRC8|hCASK|LIN2 antibody Lin2 homolog|CAMGUK, drosophila, homolog of antibody casK|Calcium/calmodulin dependent serine protein kinase MAGUK family|Vertebtate LIN2 homolog|CAGH39|FGS4|Calcium/calmodulin-dependent serine protein kinase|Caki|Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase|Calcium/calmodulin dependent serine protein kinase|DXPri1|Trinucleotide repeat containing 8|CSKP_HUMAN|Peripheral plasma membrane protein CASK|LIN 2|MICPCH|MRXSNA|CAMGUK protein|DXRib1|CAMGUK
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:140 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human CASK
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
The MAGUK (membrane-associated guanylate kinase homologs) family of proteins contain multiple protein-binding domains and are involved in cell junction organization, tumour suppression, and Signalling. CASK (also designated LIN-2) belongs to a MAGUK subfamily which is characterised by a novel domain structure that consists of a calcium/calmodulin- dependent protein kinase domain followed by PDZ, SH3 and guanylate kinase-like (GUK) domains. CASK is expressed in rat brain where it binds to cell-surface proteins, such as neurexin and syndecan, and is thought to be involved in Signalling at neuronal synapses. CASK translocates to the nucleus and interacts with Tbr-1 to form a complex, which binds to a specific DNA sequence (the T-element), and induces the expression of specific genes, including Reelin. CASK displays a transcription regulation function, which appears crucial for cerebrocortical development.
Type: Primary
Antigen: CASK
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 651-750/926
Host: Rabbit
Isotype: IgG
Reactivity: Rat