"Rod Mill"

Supplier: Bioss

Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Supplier: Bioss

Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Supplier: Bioss

Zwilch is the human homolog of the Drosophila Zwilch protein. The Drosophila Zwilch forms a complex with both ROD Rough Deal) and ZWINT (Zeste-White 10, also designated ZW10) proteins. This complex is important for chromosome segregation because it recruits cytoplasmic Dynein to the kinetochore and plays a crucial role in the spindle checkpoint. The role of Zwilch in complex is thought to be evolutionarily conserved because the human homologs of Zwilch, ZWINT and ROD coimmunoprecipitate in a human cell line called HeLa. The human Zwilch, ZWINT and ROD complex localizes to the kinetochores at prometaphase. Mutations were discovered in Zwilch, ZWINT and ROD during a screen for mutations in alleles encoding putative chromosome instability genes in cases of human colorectal cancer. These mutations may contribute in part to the chromosomal instability phenotype of colorectal tumor cells.

Supplier: Bioss

Zwilch is the human homolog of the Drosophila Zwilch protein. The Drosophila Zwilch forms a complex with both ROD Rough Deal) and ZWINT (Zeste-White 10, also designated ZW10) proteins. This complex is important for chromosome segregation because it recruits cytoplasmic Dynein to the kinetochore and plays a crucial role in the spindle checkpoint. The role of Zwilch in complex is thought to be evolutionarily conserved because the human homologs of Zwilch, ZWINT and ROD coimmunoprecipitate in a human cell line called HeLa. The human Zwilch, ZWINT and ROD complex localizes to the kinetochores at prometaphase. Mutations were discovered in Zwilch, ZWINT and ROD during a screen for mutations in alleles encoding putative chromosome instability genes in cases of human colorectal cancer. These mutations may contribute in part to the chromosomal instability phenotype of colorectal tumour cells.

Supplier: Bioss

Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Supplier: Cole-Parmer

Safely support your homogeniser while in use.

Supplier: Thermo Fisher Scientific

Blei ≥99,95% (Metall-Basis), Stäbe, Ø 6.35 mm (0.25 in)

Supplier: 3B Scientific

Plank mounted on roll. 84×118 cm.

Supplier: Cole Parmer

Der Cryo-Blade ist ein ultrahochkapazitiver kryogener Grinder zur Probenvorbereitung und -verarbeitung von bis zu 1 kg Probe. Der Cryo-Blade dosiert automatisch flüssigen Stickstoff, um die Probe auf kryogene Temperaturen zu bringen, und startet anschließend eine Mahlphase, um Proben zu pulverisieren, was zu wiederholbarer und reproduzierbarer Probenzerkleinerung führt. Kein Handling von flüssigem Stickstoff erforderlich.

Supplier: Merck

Phosphor, rot stabilisiert zur Synthese, Sigma-Aldrich®

Supplier: Bel-Art Products, a Part of SP

PP base, stainless steel mounting rod. This non corrosive, molded support stand is an excellent alternative to metal stands.

Supplier: Thermo Fisher Scientific

Aluminium ≥99,95% (Metall-Basis), Stäbe, Ø 6.35 mm (0.25 in)

Supplier: IKA

Diese Batch-Mühle zeichnet sich durch eine einfache Bedienung über Tastenfelder aus und mahlt harte, spröde, weiche und faserige Materialien, da Proben direkt in der Mahlkammer verspröden können. Auch zähe, ölige und wässrige Proben können gemahlen werden. Leicht austauschbarer Schläger/Schneider für vielfältige Anwendungen.

Supplier: Biorbyt

Anti-CRX Goat Polyclonal Antibody

Supplier: VELP SCIENTIFIC

Digital hotplate stirrers with four independent plates in CerAlTop™, ensuring precise thermoregulation of the medium, high safety, and maximum reliability. Units have epoxy painted aluminum housing.

Supplier: VELP SCIENTIFIC

Leistungsstarker digitaler Heizplattenrührer mit einer äußerst widerstandsfähigen quadratischen Keramikplatte von 26 cm (10“), ideal für Labore, die eine geräumige Arbeitsfläche benötigen. Der AREC 10 Digital bietet fortschrittliche Rühr- und Heizleistung, gewährleistet präzise Temperaturregelung, maximale Zuverlässigkeit, verbesserte Sicherheitsfunktionen und Benutzerfreundlichkeit. Das Gerät hat einen Aluminiumkörper und ein Gehäuse aus Technopolymer.