"Other Essentials"

Supplier: Abcam

Anti-DDX6 antibody [EPR27016-10] is a Rabbit Monoclonal antibody that is used in DDX6 ICC/IF, IHC-P, IP, Western Blot. Suitable for Human, Mouse, Rat samples. DDX6 is an RNA helicase involved in the regulation of mRNA metabolism, including translation suppression and mRNA degradation. It plays a crucial role in the formation of P-bodies and stress granules, which are essential for the storage and decay of mRNAs. Additionally, DDX6 is required for microRNA-induced gene silencing, impacting gene expression regulation.

Supplier: VELTEK ASSOCIATES

These high-performance cleaning agents are specifically designed for critical clean-in-place applications and are engineered to effectively remove a multitude of product residues.

Supplier: ROBU GLASFILTER

ROBU® Filter Crucibles with intergrated VitraPOR® filter provide efficient filtration for laboratory applications. Made from durable materials, these crucibles are designed for high-performance filtration, offering reliable separation of solids and liquids. Ideal for gravimetric analysis and other precise filtration processes.

Supplier: Abcam

Anti-HIRA/HIR antibody [EPR25299-11] is a Rabbit Monoclonal antibody that is used in HIRA/HIR IHC-P, IP, Western Blot. Suitable for Human, Mouse, Rat samples. HIRA (Histone Cell Cycle Regulator) is a histone chaperone that facilitates replication-independent chromatin assembly by placing the variant histone H3.3 into nucleosomes. It plays a crucial role in the formation of senescence-associated heterochromatin foci (SAHF), which are involved in the irreversible cell cycle changes in senescent cells. Additionally, HIRA is essential for the periodic repression of histone gene transcription during the cell cycle.

Supplier: Bioss

ADCK2 (aarF domain containing kinase 2), also known as AARF, is a 626 amino acid single-pass membrane protein belonging to the protein kinase superfamily and the ADCK protein kinase family. The ADCK family consists of five paralogs in human (ADCK1-5). Encoded by a gene that maps to human chromosome 7q34, ADCK2 contains one protein kinase domain. ADCK2 participates in ATP and nucleotide binding, transferase functions and protein serine/threonine kinase activities. Expression of ADCK2 inversely correlates with cellular viability, suggesting elevated expression of ADCK2 may be essential for tumour survival. ADCK2 is necessary for cell proliferation of glioblastoma multiforme (GBM), a fatal primary brain tumor containing countless genetic and epigenetic alterations.

Supplier: Abcam

Anti-CD3D+CD3G+CD3 epsilon antibody [RM1128] is a Rabbit Recombinant Multiclonal antibody that is used in CD3D+CD3G+CD3 epsilon Flow Cytometry (Intra), ICC/IF, IHC-P, IP, Western Blot. Suitable for Human, Mouse, Rat samples. CD3 is a protein complex found on T cells that is essential for T-cell receptor signaling and activation. In cancer research, CD3-targeted therapies, such as bispecific antibodies, are used to engage T cells and enhance their ability to recognize and destroy tumor cells. This approach has shown promise in treating various cancers, including both hematologic and solid malignancies.

Supplier: FUJIFILM WAKO CHEMICALS

Monothioglycerol (MTG) can be used as an alternative for 2-mercaptoethanol (2ME) since it exhibits comparable performance to 2ME when it is added to a medium in the culture of mouse ES D3 strain cells.

Supplier: Bioss

ADCK2 (aarF domain containing kinase 2), also known as AARF, is a 626 amino acid single-pass membrane protein belonging to the protein kinase superfamily and the ADCK protein kinase family. The ADCK family consists of five paralogs in human (ADCK1-5). Encoded by a gene that maps to human chromosome 7q34, ADCK2 contains one protein kinase domain. ADCK2 participates in ATP and nucleotide binding, transferase functions and protein serine/threonine kinase activities. Expression of ADCK2 inversely correlates with cellular viability, suggesting elevated expression of ADCK2 may be essential for tumour survival. ADCK2 is necessary for cell proliferation of glioblastoma multiforme (GBM), a fatal primary brain tumor containing countless genetic and epigenetic alterations.

Supplier: Cayman Chemical

TAK-242 ≥98%

Supplier: Cytiva

Capto™ HiRes Q and Capto™ HiRes S are prepacked columns for high-resolution purification of proteins and other biomolecules by ion exchange chromatography. They are well-suited for the preparation of highly pure proteins for structural studies and for protein analysis.

Supplier: Biosensis

FUNCTION: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. SUBCELLULAR LOCATION: Cytoplasm. Colocalizes with nonmuscle actin. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. INDUCTION: By apoptotic stimuli. PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane. SIMILARITY: Belongs to the ATG5 family.

Supplier: Abcam

Anti-FAK (phospho Y397 + Y576 + Y925) antibody [RM1141] is a Rabbit Recombinant Multiclonal antibody that is used in FAK (phospho Y397 + Y576 + Y925) Dot Blot, Western Blot. Suitable for Human, Mouse, Rat samples. FAK (PTK2) is a non-receptor protein-tyrosine kinase which is involved in regulation of a number of essential cellular processes, including cell cycle progression, cell migration, actic cytoskeleton organisation and formation of focal adhesions. FAK is activated by phosphorylation and recruited to focal adhesions in response to integrin signalling. Aberrant expression of FAK may play a role in tumor formation, including ovarian, breast and non-small cell lung cancers.

Supplier: Thermo Fisher Scientific

Pierce™ Recombinant Peroxidase Conjugated Protein A can be used to probe and detect rabbit and human antibodies, especially IgG isotypes, in Western blotting, ELISA, IHC and other immunoassay protocols.

Supplier: MP Biomedicals

An essential fatty acid, and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and is a constituent of animal phosphatides.

Supplier: Abcam

Anti-CRBN antibody [EPR28739-64] is a Rabbit Monoclonal antibody that is used in CRBN Flow Cytometry (Intra), IP, Western Blot. Suitable for Human, Mouse samples. Cereblon (CRBN) is a multifunctional protein located in the cytoplasm, nucleus, and peripheral membranes of the human tissues. CRBN is closely related to the proliferation and metabolism of normal cells as well as tumor cells.It is part of the CRL4 CRBN ubiquitin E3 ligase complex, which is crucial for the action of immunomodulatory drugs (IMiDs) like lenalidomide and pomalidomide. These drugs bind to CRBN, leading to the degradation of transcription factors Ikaros and Aiolos, which are essential for myeloma cell survival. Additionally, novel cereblon E3 ligase modulators (CELMoDs) are being developed to overcome resistance to IMiDs, offering new therapeutic options for patients with CRBN mutation.

Supplier: MP Biomedicals

Tryptone is a pancreatic digest of casein, utillised as a source of nitrogen in many culture media for growing bacteria as well as fungi.