DAPT ≥98% (durch NMR)
Product Details & Documents
gamma-Secretase inhibitor
Cell permeable inhibitor of γ-secretase (IC50=115nM for total β-amyloid, IC50=200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD)Does not inhibit presenilinase. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.
- CAS Nummer:208255-80-5
- Formel:C₂₃H₂₆F₂N₂O₄
- MDL-Nummer:MFCD04974585
- Molekulargewicht:432.47 g/mol
Technische Daten
Technische Daten
- VE:5 mg
Technische Daten
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