Human Recombinant IL-10 (CTGrade GMP) (from E. coli)

Supplier: Shenandoah Biotechnology

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Supplier: Shenandoah Biotechnology

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About this item

IL-10 is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells.

High quality
Low endotoxin
Lot-to-lot consistency
Animal free
Manufactured following GMP guidelines

Inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFNγ), tumor necrosis factor alpha (TNFα), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells
Suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells
The biological activity of CTGrade GMP interleukins and growth factors is standardised, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance

Host Cell Protein: ≤30 ng/ml
Host Cell DNA: ≤0,01 ng/ml
Sterility testing: No Growth
Mycoplasma: Negative

Caution: For research use or further manufacturing only.

Specifications

Konjugation:
Unconjugated
Protein-Funktion:
Cytokine
Protein/Peptid-Typ:
Rekombinant
Ursprung:
E. coli
Spezies:
Human
Lagerbedingungen:
At or below –20 °C
Endotoxingehalt:
Endotoxin LAL (EU/µg) ≤0,05
Biologische Aktivität:
Bioactivity Assay: Proliferation of MC/9, ED₅₀ ≤5 ng/ml, Bioactivity ≥5,0×10³ IU/µg
Gen-ID:
P22301
Reconstitution instructions:
Sterile water at 0,1 - 0,5 mg/ml
Frei von Endotoxinen:
N
Frei von Trägern:
Y
Frei von Proteasen:
N
Tierfrei:
Y
Proteinsynonym:
B-TCGF|TGIF|CSIF
Protein/Peptid-Name:
CTGrade GMP IL-10
Purity:
≥97%
Molecular weight:
18,8 kDa
Sequence:
MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Endotoxinspiegel:
Low
Zusammensetzung:
10 mM Sodium phosphate, pH 7,5
Frei von Nukleasen:
N
Sorte:
GMP
Transporttemperatur:
Ambient
Validierte Anwendungen:
Bioassay