Über diesen Artikel
IL-7 promotes the stimulation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. IL-7, along with IL-2, 15, and 21, is a member of the common gamma (γc) chain cytokine family.
- High Quality
- Low Endotoxin
- Lot-to-lot Consistency
- Animal Free
- Manufactured following GMP guidelines
Secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. Signals through its receptor (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and natural killer cells. Is a regulator of intestinal mucosal lymphocyte proliferation. Promotes favorable phenotypes in adoptive cellular therapies such as CAR-T cell therapy when combined with IL-15. The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.
Host cell Protein: ≤30 ng/ml
Host cell DNA: ≤0,01 ng/ml
Sterility testing: No growth
Mycoplasma: Negative
Technische Daten
- Konjugation:Unconjugated
- Protein-Funktion:Cytokine
- Protein/Peptid-Typ:Rekombinant
- Ursprung:E. coli
- Spezies:Human
- Lagerbedingungen:At or below –20 °C
- Endotoxingehalt:Endotoxin LAL (EU/µg) ≤0,05
- Biologische Aktivität:Bioactivity assay: Proliferation using PHA-activated PBMC, ED50 ≤0,5 ng/ml, Bioactivity ≥1,2x10⁵ IU/µg
- Gen-ID:P13232
- Reconstitution instructions:Sterile water at 0.1 - 0.5 mg/ml
- Frei von Endotoxinen:N
- Frei von Trägern:Y
- Frei von Proteasen:N
- Tierfrei:Y
- Proteinsynonym:Lymphopoietin 1 (LP-1)|pre-B cell Factor
- Protein/Peptid-Name:IL-7
- Purity:≥97%
- Molecular weight:17,5 kDa
- Sequence:MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH
- Endotoxinspiegel:Low
- Zusammensetzung:20 mM sodium phosphate, pH 7,5
- Frei von Nukleasen:N
- Sorte:CTGrade GMP
- Transporttemperatur:Ambient
- Validierte Anwendungen:Bioassay