DAPT ≥98% (durch NMR)

Anbieter: Enzo Life Sciences

DAPT ≥98% (durch NMR)

Anbieter: Enzo Life Sciences

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gamma-Secretase inhibitor

Cell permeable inhibitor of γ-secretase (IC50=115nM for total β-amyloid, IC50=200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD)Does not inhibit presenilinase. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.

Synonyme: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate, (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu, (3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester

CAS Nummer:208255-80-5
Formel:C₂₃H₂₆F₂N₂O₄
MDL-Nummer:MFCD04974585
Molekulargewicht:432.47 g/mol

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gamma-Secretase inhibitor

Cell permeable inhibitor of γ-secretase (IC50=115nM for total β-amyloid, IC50=200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD)Does not inhibit presenilinase. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.

Synonyme: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate, (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu, (3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester

CAS Nummer:208255-80-5
Formel:C₂₃H₂₆F₂N₂O₄
MDL-Nummer:MFCD04974585
Molekulargewicht:432.47 g/mol

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