Human recombinant cGAS (from E. coli)

100 µG

Catalog # CAYM25001-100

Supplier: Cayman Chemical

Human recombinant cGAS (from <i>E. coli</i>)

Catalog # CAYM25001-100

Supplier: Cayman Chemical

CAS Number:

Human recombinant cGAS (from <i>E. coli</i>)

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Specifications

CAS Number:

Price

SFr. 820.00

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Product Details & Documents

UniProt: Q8N884

Cyclic GMP-AMP (cGAMP) synthase (cGAS) (161-522) is a truncated form of cGAS (Item No. 22810) that contains the nucleotidyltransferase and Mab21 domains. cGAS is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates stimulator of interferon genes (STING), leading to activation of the type I interferon (IFN) pathway. In vitro, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS^-/-) mice do not produce type I IFNs following DNA transfection or DNA virus infection. Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses. In vivo, cGAS^-/- mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.

Used for: Innate Immunity, Infectious Disease, Intracellular Signalling

Specifications

VE:
100 µG
Zusammensetzung:
50 mM HEPES, pH 8,0, 150 mM sodium chloride, 1 mM DTT, and 10% glycerol
Cat. No.:
CAYM25001-100
Ursprung:
E. coli
Molekulargewicht:
44,6 kDa
Konjugation:
Unconjugated
Enzym-Typ:
Rekombinant
Enzym-Synonyme:
C6orf150, 2'3'-cGAMP Synthease, cGAMP Synthase, h-cGAS, Cyclic GMP-AMP Synthase, Mab-21 domain containing protein 1, MB21D1
Purity:
≥90% estimated by SDS-PAGE
Spezies:
Human
Enzymname:
cGAS
Lagerbedingungen:
–80 °C
Shipping conditions:
–80 °C, dry ice