Interferon gamma (IFN-γ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-γ is produced by T cells and natural killer cells following antigen-specific activation. IFN-γ binds IFN-γ receptors (IFN-γ R1 and IFN-γ R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-γ-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Human IFN-γ is not cross-reactive with mouse IFN-γ.
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A COA is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions. This product is for research use only and is not for use in humans.
- Konjugation:Unconjugated
- Protein-Funktion:Cytokine
- Protein/Peptid-Typ:Rekombinant
- Ursprung:E. coli
- Spezies:Human
- Lagerbedingungen:–20 °C
- Endotoxingehalt:Endotoxin LAL (EU/µg) ≤0,1
- Biologische Aktivität:Bioactivity assay: Viral challenge assay using EMC virus on A549 cells, ED50 ≤0,75 ng/ml, Bioactivity ≥1,3×10⁶ units/mg
- Gen-ID:P01579
- Reconstitution instructions:Sterile water at 0.1 mg/ml
- Frei von Endotoxinen:N
- Frei von Trägern:Y
- Frei von Proteasen:N
- Tierfrei:N
- Proteinsynonym:Type II interferon|T cell interferon|MAF|Immune Interferon
- Protein/Peptid-Name:IFNg
- Purity:≥95%
- Molecular weight:16,9 kDa
- Sequence:MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
- Endotoxinspiegel:Low
- Zusammensetzung:10 mM sodium phosphate, 50 mM sodium chloride, pH 7,5
- Frei von Nukleasen:N
- Sorte:RUO
- Transporttemperatur:RT
- Validierte Anwendungen:Bioassay