CMRF35-like molecule 6 (CLM-6) is also known as CD300 antigen-like family member C, CMRF35-A1, Immunoglobulin superfamily member 16 (IgSF16) , CD antigen CD300c, which belongs to the CD300 family. CLM-6 contains one Ig-like V-type (immunoglobulin-like) domain. CD300a/c RNA and surface expression were downregulated after stimulation of plasmacytoid dendritic cells (pDCs) with TLR7 and TLR9 ligands. Exogenous interferon (IFN)-alpha down-regulated CD300a/c expression. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs. CD300a and CD300c are indistinguishable on the surface of NK cells.