α1-antitrypsin, 52kDa, is the prototypic member of the serine protease inhibitor (serpin) superfamily, which have a major role in inactivating neutrophil elastase and other proteases to maintain protease-antiprotease balance. The protein is synthesized mainly in the liver, but exerts its main function in the lung where it inhibits a variety of serine proteases, but primarily neutrophil elastase. It provides more than 90% of the antiproteolytic shield of the lower respiratory tract protecting the elastic tissue from degradation. Disorders of the enzyme include α 1-antitrypsin deficiency, a hereditary disorder in which lack of α 1-antitrypsin leads to uninhibited tissue breakdown during inflammation. This causes pulmonary emphysema and leads to liver cirrhosis in severe cases.

Western Blot: 0.1 ?g/ml; Immunohistochemistry: Paraffin-embedded sections;

Type: Primary
Antigen: SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1)
Clonality: Monoclonal
Clone: 48D2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human