"Thermo Scientific"

Supplier: Thermo Scientific

This antibody is predicted to react with canine, mouse and rat based on sequence homology. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Supplier: Thermo Scientific

Pierce™ HRP conjugated avidin is used in biotin-based detection methods, including Western blotting or ELISA detection with appropriate enzyme substrates.

Supplier: Thermo Scientific

Pierce™ Slide-A-Lyzer™ Dialysis Flasks facilitate simple and effective removal of buffer salts and small contaminants from proteins and other macromolecules in sample volumes up to 250 ml.

Supplier: Thermo Scientific

This antibody is predicted to react with bovine and mouse based on sequence homology. This gene is a member of the insulin-like growth factor binding protein family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

Supplier: Thermo Scientific

This antibody is predicted to react with mouse and rat based on sequence homology. PEX14 belongs to the peroxin 14 family. It is a component of the peroxisomal translocation machinery with PEX13 and PEX17 and interacts with both the PTS1 and PTS2 receptors. PEX14 binds directly to PEX17. Defects in PEX14 are the cause of peroxisome biogenesis disorder complementation group K (PBD-CGK) [MIM:601791] and Zellweger syndrome (ZWS) [MIM:214100].

Supplier: Thermo Scientific

This antibody is predicted to react with mouse based on sequence homology. The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.

Supplier: Thermo Scientific

This antibody is predicted to react with mouse and rat based on sequence homology. MOB4A is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob4A regulates NDR1 and NDR2 kinase activity, widely expressed nuclear serine-threonine kinases that have been implicated in cell proliferation and/or tumor progression.

Supplier: Thermo Scientific

Host: Rabbit Species Reactivity: Human (Hu) Immunogen: Synthetic peptide from the N-terminal region of human DCT conjugated to KLH.

Supplier: Thermo Scientific

Recommended Dilutions: Western Blot: 1-3 ug/ml

Supplier: Thermo Scientific

Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

Supplier: Thermo Scientific

This antibody is predicted to react with mouse based on sequence homology. DIPA functions as a transcriptional repressor. It may inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. It may function in adipocyte differentiation, negatively regulating mitotic clonal expansion.

Supplier: Thermo Scientific

This antibody is predicted to react with bovine, canine and rat based on sequence homology. This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined.

Supplier: Thermo Scientific

CD105 is a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in its gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.

Supplier: Thermo Scientific

Use performance level 1 Thermo Scientific™ SureSTART™ 2 ml glass crimp top vials for everyday chromatography analysis. They provide an affordable choice and can be used with all GC and HPLC/UHPLC instrument types.

Supplier: Thermo Scientific

Current literature indicates that mammaglobin, as measured by the ELISA, holds significant promise for breast cancer screening with the realistic potential to impact management of this disease.

Supplier: Thermo Scientific

Host: Rabbit Species Reactivity: Human (Hu) Mouse (Ms) Immunogen: Synthetic peptide from the N-terminal region of human MEP1A conjugated to KLH.