977 Results for: "STEMCELL Technologies"

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against mouse CD25, unconjugated.

Supplier: STEMCELL Technologies

Rat monoclonal antibody against human IL-4, unconjugated.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2a antibody against mouse CD19, unconjugated.

Supplier: STEMCELL Technologies

Rabbit polyclonal antibody against human, mouse, rat cytokeratin 20.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched non-human primate CD8+ T cells

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of any cells with your own mouse IgG1 antibody.

Supplier: STEMCELL Technologies

Semi-solid methylcellulose-based medium for selection and cloning of suspension-adapted and adherent cells (serum-containing).

Supplier: STEMCELL Technologies

Interleukin 11 (IL-11) is a pleiotropic cytokine with effects on various tissues including the bone marrow, brain, and intestinal mucosa (Du andamp; Williams). It belongs to the IL-6 family of cytokines that share a common signal transducer, gp130. IL-11 induces the proliferation of hematopoietic stem cells (Lemoli et al.) and megakaryocytic progenitor cells (Bruno et al.), the maturation of megakaryocytes (Burstein et al.), and the production of platelets (Neben et al.). IL-11 is produced by a variety of cell types including hematopoietic cells, mesenchymal cells, epithelial cells, and neuronal cells. It was first cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102 (Kawashima et al.). The binding of IL-11 to its receptor induces heterodimerization with the gp130 subunit and activation of JAK tyrosine kinases. IL-11 was the first pharmacologic agent approved for the treatment of chemotherapy-induced thrombocytopenia. IL-11 also plays a role in cancer progression by inducing the proliferation of epithelial cancer cells and the survival of metastatic cells at distant organs. Recently, IL-11 has gained interest for its role in the pathogenesis of diseases in dysregulated mucosal homeostasis associated with STAT3 upregulation, including gastrointestinal cancers (Putoczki et al.).

Supplier: STEMCELL Technologies

Mouse monoclonal antibody against human, cynomolgus IL-2.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee, gibbon TRA-2-54 (tissue non-specific alkaline phosphatase), unconjugated.

Supplier: STEMCELL Technologies

Oncostatin M (OSM) is a member of interleukin 6 (IL-6) family of cytokines and bears close resemblance to leukemia inhibitory factor (LIF) and granulocyte colony-stimulating factor (G-CSF) in amino acid sequence and its modulation of differentiation in a variety of cell types (Rose and Bruce). OSM signals through type I receptor (consisting of gp130 and LIF receptor [LIFR]) and type II receptor (consisting of gp130 and OSM receptor [OSMR]), which eventually activate the JAK/STAT pathway (Auguste et al.; Gómez-Lechón). OSM is primarily produced by activated T cells and monocytes, and also by activated macrophages, neutrophils, mast cells, and dendritic cells. OSM is also produced within the bone microenvironment by cells of both hematopoietic and mesenchymal origin, including osteocytes and osteoblasts. OSM is involved in differentiation, cell proliferation, hematopoiesis, and inflammation, and also has been shown to have implications in liver development and bone formation and resorption (Sims and Quinn; Tanaka and Miyajima). This product is animal component-free.

Supplier: STEMCELL Technologies

Rat monoclonal antibody against mouse, hamster CD4, APC-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgM antibody against human, mouse, rat oligodendrocyte marker O4, unconjugated.

Supplier: STEMCELL Technologies

Hamster (Armenian) monoclonal antibody against mouse T cell receptor beta, PE-conjugated.

Supplier: STEMCELL Technologies

For characterization of gene expression associated with hPSC naïve or primed states.

Supplier: STEMCELL Technologies

Rat monoclonal antibody against human IL-4, APC-conjugated.

Supplier: STEMCELL Technologies

For differentiation of human ES or iPS cells into erythroid progenitor cells.

Supplier: STEMCELL Technologies

Apoptosis staining and detection kit - 100 tests.

Supplier: STEMCELL Technologies

Dulbecco's Modified Eagle's Medium (DMEM) with 4500 mg/l D-glucose.

Supplier: STEMCELL Technologies

Medium for the culture and differentiation of human monocytes into dendritic cells and their maturation.

Supplier: STEMCELL Technologies

Serum- and xeno-free medium for expansion of human pluripotent stem cell-derived endothelial cells.

Supplier: STEMCELL Technologies

Epidermal growth factor receptor (EGFR) is a type I transmembrane protein and receptor tyrosine kinase. EGFR has been shown to bind to some members of the EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, epiregulin, heparin-binding EGF, and neuregulin-2α. EGFR ligand binding induces homodimerization, as well as heterodimerization of EGFR with ErbB2 or with ligand-activated ErbB3 or ErbB4 (Schlessinger). Dimerization results in kinase activation, phosphorylation, and cell signaling, mediated primarily through MEK/ERF and AKT pathways (Navlonic et al.). EGFR signaling has been shown to regulate cell proliferation, differentiation, motility, and apoptosis. Elevated levels of EGFR have been correlated with carcinogenesis (Maihle et al.). Protein contains a His-residue tag at the carboxyl end of the polypeptide chain.

Supplier: STEMCELL Technologies

Column-free immunomagnetic positive selection of human CD3+ cells for HLA analysis.

Supplier: STEMCELL Technologies

Amine-labeling fluorescent dye for live/dead staining of mammalian cells - 100 tests.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human B cells for HLA analysis
EasySep™ kit with RoboSep™ buffer and RoboSep™ filter tips

Supplier: STEMCELL Technologies

Immunodensity isolation of untouched mesenchymal stem cells.

Supplier: STEMCELL Technologies

Immunodensity pre-enrichment of untouched progenitor cells from cord blood.

Supplier: STEMCELL Technologies

Stimulating T cells with HHV8 (K8) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HHV8 (K8) peptide pool is a lyophilized mixture of 57 peptides from protein K8 alpha of human herpesvirus 8 (HHV-8), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 237 on K8. A basic leucine zipper (bZip) protein that associates with the lytic origin of HHV8 (Lin et al.), K8 is thought to play a role in lytic DNA replication, as a trans-acting factor (AuCoin et al.). It has also been found to modulate the activity of the transcriptional transactivator K-Rta (Izumiya et al.), and has an autoregulatory function (Wang et al.). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of neutrophils directly from whole blood

Supplier: STEMCELL Technologies

Cell detachment solution.