977 Résultats pour : « STEMCELL Technologies »

Supplier: STEMCELL Technologies

Mouse monoclonal antibody against human, monkey CD137 (ILA).

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2a, antibody against human CD3, FITC-conjugated.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against mouse CD25, unconjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal antibody against human, rhesus CD80 (B7-1), APC-conjugated.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2a antibody against mouse CD19, unconjugated.

Supplier: STEMCELL Technologies

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG encoded common cytokine receptor γ-chain (Parrish-Novak et al.; Ozaki K et al. 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki et al. 2002; Nurieva et al.). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser et al.). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland et al.) and control of T cell autoimmunity by regulatory B cells (Yoshizaki et al.).

Supplier: STEMCELL Technologies

Rat monoclonal IgG2a antibody against mouse CD150 (SLAM), unconjugated.

Supplier: STEMCELL Technologies

Rat monoclonal antibody against human IL-4, unconjugated.

Supplier: STEMCELL Technologies

Rat monoclonal antibody against mouse CD127, PE-conjugated.

Supplier: STEMCELL Technologies

Interleukin 22 (IL-22) is a class 2 α-helical cytokine that signals through the class 2 cytokine receptor and activates the JAK/STAT pathway. IL-22 is secreted by Th1, Th2, Tc22, and γδ T cells, dendritic, mast and NK cells. It stimulates expression of antimicrobial peptides from epithelial cells, thus hindering bacterial infections. Depending on the interactions with other cytokines, IL-22 can either promote inflammation or prevent tissue destruction by regulating host defense and tissue homeostasis at barrier surfaces (Sonnenberg et al.).

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD5, unconjugated.

Supplier: STEMCELL Technologies

Nerve growth factor (NGF)-beta is a prototypical member of the neurotrophin family and has a role in the survival and growth of neural cells, regulating cell growth, promoting differentiation into neurons, and neuron migration. The beta subtype of NGF is biologically active in comparison to the alpha-2 and gamma-2 subtypes. NGF-beta in its secreted form can bind to tyrosine kinase A (trkA) receptor with high affinity and to p75 (NTR) with low affinity (Levi and Alemà; Sofroniew et al.). NGF has been shown to possess pro-inflammatory and pro-fibrogenic properties (Micera et al.). It has also been shown that overexpression of NGF-beta promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathways (Yuan et al.). This product is animal component-free.

Supplier: STEMCELL Technologies

For characterization of gene expression associated with hPSC naïve or primed states.

Supplier: STEMCELL Technologies

Rat monoclonal antibody against mouse, hamster CD4, APC-conjugated.

Supplier: STEMCELL Technologies

Hamster (Armenian) monoclonal IgG1 antibody against mouse CD3e, unconjugated.

Supplier: STEMCELL Technologies

Oncostatin M (OSM) is a member of interleukin 6 (IL-6) family of cytokines and bears close resemblance to leukemia inhibitory factor (LIF) and granulocyte colony-stimulating factor (G-CSF) in amino acid sequence and its modulation of differentiation in a variety of cell types (Rose and Bruce). OSM signals through type I receptor (consisting of gp130 and LIF receptor [LIFR]) and type II receptor (consisting of gp130 and OSM receptor [OSMR]), which eventually activate the JAK/STAT pathway (Auguste et al.; Gómez-Lechón). OSM is primarily produced by activated T cells and monocytes, and also by activated macrophages, neutrophils, mast cells, and dendritic cells. OSM is also produced within the bone microenvironment by cells of both hematopoietic and mesenchymal origin, including osteocytes and osteoblasts. OSM is involved in differentiation, cell proliferation, hematopoiesis, and inflammation, and also has been shown to have implications in liver development and bone formation and resorption (Sims and Quinn; Tanaka and Miyajima). This product is animal component-free.

Supplier: STEMCELL Technologies

Apoptosis staining and detection kit - 100 tests.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, cynomolgus, cow CD117 (c-Kit), unconjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee, gibbon TRA-2-54 (tissue non-specific alkaline phosphatase), unconjugated.

Supplier: STEMCELL Technologies

Epidermal growth factor (EGF) is the founding member of the EGF family of proteins and is characterized by high affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter and Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright et al.). EGF can stimulate the proliferation of mouse embryonic stem cells or induce the terminal differentiation/growth inhibition of A431 cells (Heo et al.).

Supplier: STEMCELL Technologies

Mouse monoclonal antibody against human CD69 (AIM).

Supplier: STEMCELL Technologies

Semi-solid methylcellulose-based medium for selection and cloning of suspension-adapted and adherent cells (serum-containing).

Supplier: STEMCELL Technologies

Animal component-free collagenase for the digestion of native collagen fibrils.

Supplier: STEMCELL Technologies

Rabbit polyclonal antibody against human, mouse, rat chromogranin A.

Supplier: STEMCELL Technologies

Hamster (Armenian) monoclonal antibody against mouse T cell receptor beta, PE-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2a antibody against human CD51 (integrin αV), unconjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD8a, unconjugated.

Supplier: STEMCELL Technologies

Interleukin 1 beta (IL-1β) is synthesized as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. Mice deficient in IL-1β do not show phenotypical differences from wild-type mice; however, they have a reduced response to inflammation, suggesting that IL-1β plays a key role in inflammatory diseases (Dinarello).

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against human, mouse, rhesus CD11b.

Supplier: STEMCELL Technologies

Rabbit polyclonal antibody against human, mouse, rat cytokeratin 20.