"Peprotech"

Supplier: Peprotech

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.

Supplier: Peprotech

Recombinant HumansCD28 Fc, Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses, Source: CHO cells, Determined by its ability to bind its principal binding partner (B7-1) in a functional ELISA, Synonyms: T-cell-specific surface glycoprotein CD28, Size: 20UG

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human Vaspin. Anti­Human Vaspin­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Biotinylated p16-INK4a-TAT, Polyclonal antibody, Host: Rabbit, Species: Human, Immunogen: E.coli derived Recombinant Human p16-INK4a-TAT, Application: Sandwich ELISA, Western Blot, Purity: affinity chromatography, Size: 25UG

Supplier: Peprotech

Serum amyloid A proteins (SAA) represents a family of apolipoproteins that circulates in association with high-density lipoproteins (HDL). The level of Apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apolipoprotein. The human SAA gene codes for a 122 amino acid nonglycosylated polypeptide, which contains an 18 amino acid N-terminal sequence. Recombinant Human Apo-SAA1 is an 11.7 kDa protein containing 105 amino acid residues.

Supplier: Peprotech

Biotinylated VEGF-B, Polyclonal antibody, Host: Rabbit, Species: Human, Immunogen: E.coli derived Recombinant Human VEGF-B, Application: Sandwich ELISA, Western Blot, Purity: affinity chromatography, Size: 25UG

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human sTRAIL Receptor-2. Anti­Human sTRAIL Receptor-2­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Murine Eotaxin-2 (CCL24). Anti­Murine Eotaxin-2 (CCL24)­specific antibody was purified by affinity chromatography employing an immobilized Murine Eotaxin-2 matrix.

Supplier: Peprotech

IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8 and GM-CSF, and inhibits hemopoiesis of myeloid progenitor cells in colony-forming assays. Recombinant Human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human APRIL. Anti­Human APRIL­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human Oncostatin M. Anti­Human Oncostatin M­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. Human and murine TPO exhibit cross-species reactivity. The human TPO gene encodes for a 353 amino acid glycoprotein, which contains a 21 amino acid signal sequence, a 15 amino acid erythropoietin-like domain, and a highly glycosylated 179 amino acid C-terminal domain. Recombinant Human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

Supplier: Peprotech

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. BD-4 is expressed in the testes, stomach, uterus, neutrophils, thyroid, lungs and kidneys. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes. Recombinant Human BD-4 is a 6.0 kDa protein containing 50 amino acid residues.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Human IL-1β. Anti­Human IL-1β­specific antibody was purified by affinity chromatography employing an immobilized Human IL-1β matrix.

Supplier: Peprotech

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acid residues.

Supplier: Peprotech

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant Rat sRANK Ligand is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).