9549 Résultats pour : « Biotium »

Supplier: Biotium

This conjugate is prepared by labeling F(ab’)2 fragment of goat anti-mouse IgG (H+L) with CF™350 dye. CF™ dyes offer advantages in brightness, photostability, and specificity compared to other fluorescent dyes. Blue fluorescent CF™350 (Ex/Em 347/448 nm) is more water-soluble, more photostable and at least 50% more fluorescent on proteins compared to the traditional blue dye AMCA.

Supplier: Biotium

Min X Bv Ch Ft GP Hs Hu Rb Rt Sh SHm. CF488A antibodies are labeled with green fluorescent CF488A. Green fluorescent CF488A is a spectrally similar to fluorescein but with brighter and more photostable fluorescence.

Supplier: Biotium

CF594 antibodies are affinity-purified antibodies labeled with deep red CF594 dye which is spectrally similar to Alexa Fluor 594 or Texas Red dye but with significantly brighter fluorescence and with excellent photostability.

Supplier: Biotium

Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Supplier: Biotium

Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast.

Supplier: Biotium

CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Supplier: Biotium

CD79A Monoclonal antibody, Clone: JCB117 + HM47/A9, Host: Mouse, Species reactivity: Mouse, Monkey, Pig, Cow, Rat, Human, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: A synthetic peptide corresponding to aa 202-216, Application: IHC, Size: 100uL

Supplier: Biotium

This antibody reacts with the TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with this MAb is completely blocked by the peptide used for raising this antibody. TGF alpha (aa50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.

Supplier: Biotium

Cytokeratin 19 Monoclonal antibody, Clone: A53-B/A2.26, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: purified, Immunogen: Human breast cancer MCF-7 cells, Synonyms: k19, k1cs, krt19, Application: IF, IHC, FC, Size: 100uL

Supplier: Biotium

Cytokeratin 18 Monoclonal antibody, Clone: KRT18/834, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: purified, Immunogen: Recom full-length human KRT18 protein, Synonyms: K18, Application: IF, IHC, Size: 500 uL

Supplier: Biotium

Cyclin A2 Monoclonal antibody, Clone: E67, Host: Mouse, Species reactivity: Mouse, Mink, Green monkey, Monkey, Cow, Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Full length bovine Cyclin A, Synonyms: CCN1, CCNA, CCNA2, Application: IF, Size: 100uL

Supplier: Biotium

Cytokeratin 18 Monoclonal antibody, Clone: DC10, Host: Mouse, Species reactivity: Human, Isotype: IgG1, Conjugate: CF488A, Immunogen: PMC-42 human breast carcinoma cells, Synonyms: K18, Application: IF, IHC, WB, FC, Size: 100uL

Supplier: Biotium

Cyclin A2 Monoclonal antibody, Clone: E67, Host: Mouse, Species reactivity: Mouse, Mink, Green monkey, Monkey, Cow, Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Full length bovine Cyclin A, Synonyms: CCN1, CCNA, CCNA2, Application: IF, Size: 500uL

Supplier: Biotium

Helicobacter pylorI, Monoclonal antibody, Clone: HP/212, Host: Mouse, Species reactivity: Helicobacter pylori, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Total sonicate of Helicobacter pylori, Synonyms: H. Pylori, Application: IF, Size: 500uL

Supplier: Biotium

Helicobacter pylorI, Monoclonal antibody, Clone: HP/212, Host: Mouse, Species reactivity: Helicobacter pylori, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Total sonicate of Helicobacter pylori, Synonyms: H. Pylori, Application: IF, Size: 500uL

Supplier: Biotium

Helicobacter pylorI, Monoclonal antibody, Clone: HP/212, Host: Mouse, Species reactivity: Helicobacter pylori, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Total sonicate of Helicobacter pylori, Synonyms: H. Pylori, Application: IF, Size: 500uL

Supplier: Biotium

CD98 exits as a heterodimer containing a disulphide-linked glycosylated heavy chain and a non-glycosylated light chain. It is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through disulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Supplier: Biotium

CD98 exits as a heterodimer containing a disulphide-linked glycosylated heavy chain and a non-glycosylated light chain. It is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through disulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.

Supplier: Biotium

Cytokeratin 19 Monoclonal antibody, Clone: KRT19/799 + KRT19/800, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: purified, Immunogen: Human breast cancer MCF-7 cells, Synonyms: k19, k1cs, krt19, Application: IF, Size: 100uL

Supplier: Biotium

TNF alphA, Monoclonal antibody, Clone: TNFA/1172, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Recombinant human TNF-alpha, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

Cdc20 Monoclonal antibody, Clone: AR12, Host: Mouse, Species reactivity: Human, Isotype: IgG1, Conjugate: purified, Immunogen: Urea-denatured His6 Cdc20 human recombinant protein, Synonyms: CDC20, CDC20A, p55CDC, P55CDC-LSB, Application: IF, IHC, FC, Size: 100uL

Supplier: Biotium

Cytokeratin 8 Monoclonal antibody, Clone: B22.1, Host: Mouse, Species reactivity: Rabbit, Pig, Cow, Sheep, Human, Isotype: IgG, K, Conjugate: CF647, Immunogen: Cytoskeletal preparation, Synonyms: CYK8, Application: IF, Size: 500 uL

Supplier: Biotium

This antibody recognizes a protein of 205 kDa-220 kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4 T-cells, 50% of peripheral CD8 T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4 or CD8 T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO ve) from B cell lymphomas (CD45RA ve).

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Supplier: Biotium

This antibody recognizes actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. Actin can be resolved on the basis of its isoelectric points into three distinctive components: alpha, beta, and gamma in order of increasing isoelectric point. Anti-muscle specific actin recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are non-reactive. Also, neoplastic cells of non-muscle-derived tissue such as carcinomas, melanomas, and lymphomas are negative.It stains tumors of smooth muscle (leiomyomas and leiomyosarcomas) as well as skeletal muscle (rhabdomyomas and rhabdomyosarcomas).

Supplier: Biotium

TNF alphA, Monoclonal antibody, Clone: TNF656, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Recombinant human TNF-alpha, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

HER-2 / CD340, Monoclonal antibody, Clone: HRB2/282, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Recombinant intracellular domain of human HER-2 protein, Synonyms: p185, CD340, Verb b2, Size: 500uL

Supplier: Biotium

HCG-beta, Monoclonal antibody, Clone: HCGb/54, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF594, Immunogen: Recombinant hCG beta protein (HCGb/54 and HCGb/459), Synonyms: CG-beta; CGB3; CGB5; CGB7; CGB8, Application: Immunofluorescence, Size: 500uL

Supplier: Biotium

HCG-beta, Monoclonal antibody, Clone: HCGb/54, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF647, Immunogen: Recombinant hCG beta protein (HCGb/54 and HCGb/459), Synonyms: CG-beta; CGB3; CGB5; CGB7; CGB8, Application: Immunofluorescence, Size: 500uL

Supplier: Biotium

This antibody recognizes a 180-185 kDa protein, identified as isoform of leukocyte common antigen (CD45RO). This antibody reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. It shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. Reportedly, it is useful to identify T-cell lymphomas and leukemias. It rarely stains NK cells or B-cell lymphomas.

Supplier: Biotium

This antibody recognizes a phosphor-protein of 45 kDa, identified as MyoD1. This MAb does not cross react with myogenin, Myf5, or Myf6. Antibody to MyoD1 labels the nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal adult tissue, but is highly expressed in the tumor cell nuclei of rhabdomyosarcomas. Occasionally nuclear expression of MyoD1 is seen in ectomesenchymoma and a subset of Wilm s tumors. Weak cytoplasmic staining is observed in several non-muscle tissues, including glandular epithelium and also in rhabdomyosarcomas, neuroblastomas, Ewing s sarcomas and alveolar soft part sarcomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.