7583 Résultats pour : « Bachem Americas »

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1G CAS: 38062-72-5 C12H20N4O3 FW: 268.32

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Sequence: Fmoc-D-Phe-OH

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Sequence: Fmoc-Val-OSu

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Sequence: Fmoc-Arg(Mtr)-OH

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The dipeptide Leu-Ala inhibits ubiquitin-mediated protein degradation. It has been shown to act in vitro as an inhibitor of neurite outgrowth of PC12 cells.

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An effector dipeptide that enhances the catalytic activity of the proenzyme trypsinogen. Forms nanotubes as its retroanalog H-Val-Ile-OH. These pores absorb and store gases as methane or hydrogen.

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Contrary to similar non-polar dipeptides as Ile-Leu or Ile-Val, Ile-Ile crystallizes forming hydrophobic columns.

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Sequence: Fmoc-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

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Sequence: Fmoc-Gln(Mtt)-OH

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Sequence: Fmoc-2-Nal-OH

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These peptides correspond to the C-terminus of the 65-residue polypeptide hirudin, a potent thrombin inhibitor found in the saliva of the leech Hirudo medicinalis. Treatment of hirudin with carboxypeptidase Y has shown that the last 5 amino acids are essential for its inhibitory activity.

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CNP, a member of the natriuretic peptide family, was first identified in porcine brain and later found in other mammals as well as non-mammals. Processing of the CNP precursor gives rise to CNP-22 and its N-terminally elongated form, CNP-53. The CNPs share considerable sequence homology with ANP and BNP within the disulfide loop and exert similar pharmacological actions, although with different relative potencies. CNP-22 is a potent and selective activator of the human BNP cell surface receptor, a transmembrane guanylyl cyclase. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system.

Supplier: Bachem Americas

Human galanin, a 30-amino acid non-amidated peptide, has originally been isolated from colon and pituitary. Its sequence differs from that of rat and porcine galanins by 4 and 6 amino acids in the C-terminal moiety, respectively. Synthetic human galanin is equipotent to the rat peptide in the isolated rat fundus muscle strip bioassay. Both peptides also fully activate the rat galanin receptor, indicating the importance of the conserved N-terminal portion of galanin for receptor interaction. Galanin, which is widely distributed in the CNS, and GAL receptors (GALR) are overexpressed in limbic brain regions associated with cognition in Alzheimer disease. As galanin inhibits acetylcholine release, galanin antagonists have gained interest in AD research.

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ω-Conotoxin MVIIA, originally isolated from the venom of the fish-hunting cone snail Conus magus, is a blocker of voltage-sensitive Ca²⁺ channels in neurons. The peptide has been used to identify different Ca²⁺ channel subtypes in amphibian brain.

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GGSLYSFGL-amide, a type A allatostatin.

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Xenin 25, which has 6 C-terminal amino acids in common with amphibian xenopsin, has been detected in human gastric mucosa. It stimulates the exocrine pancreatic secretion. Xenin co-excreted with the incretin GIP has gained interest in diabetes research.

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Sequence: H-Cit-OH

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Sequence: H-D-Glu-OtBu

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Sequence: L-threo-Phenylserine
Synonym(s): (2S,3R)-2-Amino-3-hydroxy-3-phenylpropionic acid

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Ala-Phe was shown to be an efficient enatioselective catalyst in aldol reactions.

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Boc-LGR-pNA, a chromogenic substrate for horseshoe crab clotting enzyme, which is used in quantitative assays of endotoxin.

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Sequence: H-Arg-4MβNA

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Sequence: H-Pro-pNA

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See also C-1040, C-2345, I-1000, and L-1435.

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Sequence: H-Val-pNA · HCl

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See also H-Lys-Pro-AMC (I-1745) and H-Lys-Pro-MNA (J-1255) .

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Sequence: Bz-Arg-OEt · HCl

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Sequence: Ac-Tyr-OEt

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See also I-1350 and K-1490.

Supplier: Bachem Americas

MGP-AMC, fluorogenic substrate for methionine aminopeptidases 1D and 2.