(Trp⁴)-Kemptide
Supplier: Bachem Americas
Chocktide ((Trp⁴)-Kemptide) is readily phosphorylated by cAMP-dependent protein kinase. The phosphorylated peptide, in turn, is an effective substrate for phosphoprotein phosphatase. The changes in the substrate fluorescence intensity as a function of its phosphorylation state provide a sensitive assay of both enzyme activities.
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Mca-(Ala⁷,Lys(Dnp)⁹)-Bradykinin Trifluoroacetate
Supplier: Bachem Americas
Substrate V, Mca-RPPGFSAFK(Dnp), is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1) a membrane-bound zinc metallopeptidase that is related to neprilysin in amino acid sequence. The kcat/Km value for the hydrolysis by ECE-1 was 1.9 x 10⁷ M⁻¹s⁻¹ and 1.7 x 10⁶ M⁻¹s⁻¹ for the hydrolysis by neprilysin. This FRET substrate was hydrolyzed rapidly by stromelysin 1 (MMP-3) with kcat/Km= 218000 M⁻¹s⁻¹ and very slowly by gelatinase B (MMP-9) (kcat/Km= 10100 M⁻¹s⁻¹). There was no hydrolysis by MMP-1 and MMP-2. Mca-RPPGFSAFK(Dnp) has also found use as substrate for insulin-degrading enzyme (IDE) and ACE2.
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N-Boc-O-tert-butyl-L-serine dicyclohexylammonium salt
Supplier: Bachem Americas
Storage temperature: +5 ± 3 °C
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N-Boc-1-(2,4-dinitrophenyl)-L-histidine isopropanol
Supplier: Bachem Americas
Sequence: Boc-His(Dnp)-OH isopropanol solvate
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BOC-L-phenylalanine-N-hydroxysuccinimide ester
Supplier: Bachem Americas
Sequence: Boc-Phe-OSu
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Boc-Ala-D-Glu(OBzl)-NH₂
Supplier: Bachem Americas
Partially protected Ala-D-IsoGln and Ala-IsoGln dipeptides.
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(S)-3-Amino-4-((4-nitrophenyl)amino)-4-oxobutanoic acid hydrochloride
Supplier: Bachem Americas
Sequence: H-Asp-pNA · HCl
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Nɑ-(tert-Butoxycarbonyl)-D-asparagine
Supplier: Bachem Americas
Sequence: Boc-D-Asn-OH
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Nα-(tert-Butoxycarbonyl)-L-arginine hydrochloride
Supplier: Bachem Americas
Sequence: Boc-Arg-OH · HCl · H₂O
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Nɑ-(tert-Butoxycarbonyl)-Ndelta-carbobenzoxy-L-ornithine
Supplier: Bachem Americas
Sequence: Boc-Orn(Z)-OH
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N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid
Supplier: Bachem Americas
Sequence: Fmoc-Asp-OH
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Fmoc-Aad(otBu)-OH
Supplier: Bachem Americas
Sequence: Fmoc-Aad(OtBu)-OH
Synonym(s): Fmoc-α-aminoadipic acid-δ-t-butyl ester#(S)-2-(Fmoc-amino)-hexanedioic acid-6-t-butyl ester#Fmoc-Homoglu(OtBu)-OH
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H-Tyr-His-OH
Supplier: Bachem Americas
Both single-dose administration and repetitive oral application of the dipeptide YH significantly decreased blood pressure in spontaneously hypertensive rats.