1874 Résultats pour : « Anaspec Inc »

Supplier: Anaspec Inc

Generic substrate for fluorimetric detection of oxidases (including peroxidase) in mitochondria

Supplier: Anaspec Inc

This peptide prepared by neutralizing the TFA salt form of Aß (1-42) with a dilute sodium hydroxide solution has superior solubility and fibrillogenesis properties, and the fibrils are equally neurotoxic.
Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
MW: 4514.1+23 Da
Molecular Weight: 4514.1 + 23
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Supplier: Anaspec Inc

This is a dimethylated lysine at position 4 of the 1-21 amino acid histone H3 peptide. This form of histone methylation is characterized as being enriched around transcription start sites (TSS). It has been observed that a subgroup of genes linked to T cell functions showed high levels of H3K4me2 within their gene body. While enrichment for H3K4me2 within the gene body is a characteristic trait of expressed genes in yeast, in contrast, H3K4me2 has been shown to be predominantly enriched around the TSS in mammals.
Sequence:ART-K(Me2)-QTARKSTGGKAPRKQLA
MW:2282.6 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This 20-residue peptide, a major pathogenic T-cell epitope (161–180), is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP). It has been shown to induce posterior uveitis (EAU).
Sequence:SGIPYIISYLHPGNTILHVD
MW:2209.5 Da
% peak area by HPLC:95
Storage condition:-20° C

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This gelatin is heavily labeled with FITC, and the conjugate is a highly quenched gelatinase/collagenase substrate. It is efficiently digested by gelatinases and collagenases, releasing brightly fluorescent peptides. The increase in fluorescence upon digestion is proportional to proteolytic activity. Longer incubation may increase its sensitivity for detecting proteases.

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Hoe 140 is a stable B2 bradykinin antagonist. Based on its high potency and good tolerability, Hoe 140 is used to evaluate the role of bradykinin in human diseases.
Sequence:rRP-(Hyp)-G-(Thi)-S-(D-Tic)-(Oic)-R
MW:1304.5 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C

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(Arg)9 is a cell-permeable peptide used for drug delivery.It can traverse the plasma membrane of eukaryotic cells. This is a fluorescent (TAMRA)-labeled cell permeable peptide, Abs/Em=541/568.
Sequence:TAMRA-RRRRRRRRR
MW:1836.2 Da
% peak area by HPLC:95
Storage condition:-20° C

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7-Amino-4-methylcoumarin is used to produce fluorogenic substrates

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Plasmin belongs to the family of serine proteases

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This peptide is histone H4 (1-25) with acetylation at Lys5, Lys8, Lys12, and Lys16, followed by a C-terminal GSGS linker and a biotinylated lysine. Acetylation at Lys5, Lys8, and Lys12 is carried out by p300 protein while acetylation at Lys16 is regulated by several histone acetyltransferases. These lysine residues have been shown to have important functions in transcriptional activation, replication, and nuclear division. Acetylation of lysine residues promotes binding of transcription factors to histone H4. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVLRDN-GSGSK(Biotin)
MW:3400.9 Da
% peak area by HPLC:95
Storage condition:-20° C

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A protease-activated receptor (PAR-1) agonist peptide (P5-NH2) identified as the minimal structural motif required for retaining the full agonist activity.
Sequence:SFLLR - NH2
MW:634.1 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C

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Magainin 2 assumes an amphiphilic helix when bound to acidic phospholipids, forming a pore composed of a dynamic, peptide-lipid supramolecular complex.
Sequence:GIGKFLHSAKKFGKAFVGEIMNS
MW:2466.9 Da
% peak area by HPLC:95
Storage condition:-20° C

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Highly water soluble for microinjection

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This peptide is Histone H3 amino acid residues 1 to 10 tri-methylated at Lys-9.
Sequence:TKQTAR-K(Me3)-STGGKAPR
MW:1628.8 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

This kit is optimized to detect anti-mouse MOG (1-125) IgG. Wells are pre-coated with recombinant mouse MOG (1-125) protein and pre-blocked with BSA. The amount of anti-mouse MOG IgG in serum or cerebrospinal fluid is quantified using ELISA. Ample materials and reagents are provided to perform 96 assays.

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This sequence acts as a tethered peptide ligand. Free SFLLRN activates PAR1 independent of receptor cleavage and has been used to probe PAR1 function in various cells and tissues. This peptide is also known to be capable of activating PAR2.
Sequence:SFLLRN
MW:748.9 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C

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This peptide is amino acids 46 to 61 fragment of the hen egg lysozyme (HEL). Lysozyme is anti-bacterial enzyme found in high concentration in the egg white. HEL was used in MHC related studies, and tested as a part of antimicrobial vaccines.
Sequence:NTDGSTDYGILQINSR
MW:1753.9 Da
% peak area by HPLC:95
Storage condition:-20° C

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This is a 38 residue inactive big endothelin-1 intermediate that gives rise to a shorter active peptide produced in vascular endothelial cells.
Sequence:CSCSSLMDKECVYFCHLDIIWVNTPEHIVPYGLGSPSRS (Disulfide bridge: 1-15 and 3-11)
MW:4384.1 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C

Supplier: Anaspec Inc

This peptide is based on amino acids 73 to 83 of histone H3. Lysine 79 of Histone H3 (H3K79) has been identified as a residue for acetylation or methylation.Related Peptides: [Lys(Ac)79]-Histone H3 (73-83), H3K79(Ac), Cat# 65438 [Lys(Me3)79]-Histone H3(73-83), H3K79(Me3), Cat# 65439[Lys(biotin)79]-Histone H3 (73-83), H3K79(biotin), Cat# 65440
Sequence:EIAQDFKTDLR
MW:1336.5 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Tetramethylrhodamine-5 C2 maleimide is a good alternative to tetramethylrhodamine-5-maleimide with excitation/emission wavelength at 544/572 nm. Its spectral characteristics are very close to those of tetramethylrhodamine-5-maleimide (+2 nm). It is 40% less expensive compared to tetramethylrhodamine-5-maleimide, and can be used for thiol modification of proteins, antibodies and peptides.

Supplier: Anaspec Inc

This peptide is a control for the RGDS Fibronectin Active Fragment and other RGD-related peptides. Asp3 is replaced by Glu3 in RGDS peptide changing its properties to inhibit integrins and proteins of extracellular matrix binding.
Sequence:RGES
MW:447.5 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. MMP-10 (stromelysin 2) is involved in several pathological conditions, such as cancer, arthritis and wound healing. MMP-10 is secreted as zymogen with a prodomain, a catalytic domain, a hinge region, and a hemopexin-like domain. It can activate other MMPs such as MMP-1, MMP-8 and degrade a variety of substrates, including gelatin, collagens III, IV and V, fibronectin, aggrecan

This recombinant human MMP-10 was expressed as a pro-enzyme enzyme from its DNA sequence7 transfected into a mouse myeloma cell line, NS0. The apparent Mr on SDS-PAGE is 58-kDa. Incubation with 1 mM APMA at 37°C for 1-2 hours will activate pro-MMP-10. Its activity can be measured by FRET peptides

Supplier: Anaspec Inc

This peptide is Histone H3 amino acid residues 21 to 44 di-methylated at Lys-27 with an additional C-terminal glycine followed by a biotinylated lysine. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:ATKAAR-K(Me2)-SAPATGGVKKPHRYRPG-GK(Biotin)
MW:2945.5 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys

The sequence (Accession # NP_034944) corresponding to the extracellular domain of mouse MOG along with a 6x His tag was expressed in E. coli. The recombinant mouse MOG (M-rMOG) was purified from urea denatured bacterial lysate using immobilized metal affinity chromatography (IMAC). The molecular mass of the recombinant mouse MOG is 14.2 kDa

Supplier: Anaspec Inc

This peptide is Histone H3 amino acid residues 1 to 10 tri-methylated at Lys-4.
Sequence:ART-K(Me3)-QTARKS
MW:1188.3 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Transportan is an amphipathic antimicrobial cell-penetrating peptide.
Sequence:GWTLNSAGYLLGKINLKALAALAKKIL
MW:2841.5 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec Inc

Congo Red, UltraPure Grade, Early diagnosis and classification of amyloid deposition, Molecular Weight: 696.7, Spectral Properties: Abs/Em = 497/NA nm, Solvent System: Water, CAS number: 573-58-0, Molecular formula: C32H22N6Na2O6S2, Physical State: Solid, Storage: -20 deg C, Size: 1 g

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QXL® 670 dyes are optimized quenchers for Cy5 and Cy5-like fluorophores such as HiLyte™ Fluor 647.

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Cholecystokinin (CCK) acts both as a hormone and a neurotransmitter and is found in the GI system and the central nervous system. It is a satiety peptide that inhibits food intake.
This Cholecystokinin (CCK) analog retains all the bioactivities of CCK8, but was found to be remarkably more stable in acidic media and unaffected by air oxidation due to Met replacements (Thr 28 and Nle31 were substituted for Methionine). The predominant conformation contains a gamma-turn centered on Thr4, separated by Gly5 from a helical segment that comprises the C-terminal residues.
Sequence: RD-Y(SO3H)-TGW-Nle-DF-NH2
MW: 1251.3 Da
% Peak area by HPLC: 95
Storage condition: -20° C

Supplier: Anaspec Inc

ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions
Sequence:CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1-15 and 3-11)
MW:2492 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C