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Spécifications
- Description:FOCUS™ Global Fractionation
- Size:50 Preps
- Cat. no.:CA78000-050
- Supplier No.:786-018
Spécifications
À propos de cet article
Designed to fractionate complex biological samples into cytosolic and membrane fractions
Lipid rafts are membrane microdomains that are enriched in caveolin, cholesterol, glycolipids, sphingolipids and glycosyl-phosphatidylinositol. Lipid rafts are also known as detergent-insoluble glycolipid-enriched complexes (GEMs) or DIGs. Many signaling proteins, including glycosylphosphatidylinositol (GPI)-anchored proteins, doubly-acylated tyrosine kinases of the Src family, and transmembrane proteins, are located in lipid rafts. Lipid raft localized proteins have been shown to be involved in intracellular membrane trafficking and signaling.
Designed for >50 preps, where a prep is one of the following: 100 mg mammalian tissue, 50μL wet animal cell pellet, 50μL wet yeast pellet, 50μL wet bacteria pellet, or 250 mg plant tissue.
The resulting membrane fractions are subsequently fractionated into either peripheral and integral membrane proteins or lipid raft associated proteins and detergent soluble membrane proteins.