Zebrafish Conditioned Place Preference Chamber

The Zebrafish conditioned place preference (CPP) chamber is a widely used paradigm to evaluate the rewarding effects of food substances or psychoactive drugs.

• 2 divider slots allow the zebrafish to choose a chamber or retain the zebrafish in the center area
• Floor is clear to allow for location preferences
• Customized floor patterns can be included in your order upon request
• Sizing modifications can be requested within 50% of the original sizing

In the CPP task, the positive-reinforcing effects of drugs are assessed by the preference of the zebrafish to linger in the environment that was previously conditioned with a substance (drug). The CPP paradigm exploits the natural tendency of the zebrafish to choose black over white. In this assay, the primary stimulus (drug) serves as an unconditioned stimulus. When it is paired with a secondary stimulus (visual cue), which acts as a conditioned stimulus, an approaching behavior for the paired environment is evoked. (Darland & Dowling, 2001).