Human Recombinant LIF (from E. coli)
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Product Details & Documents
LIF is a pleiotrophic factor produced by multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor. Recombinant Human LIF is a 19.7 kDa protein containing 180 amino acid residues, including three disulfide bonds.
Spécifications
Spécifications
- Taille:50 µg
- Protein/peptide name:LIF
- Protein synonyms:Leukemia Inhibitory Factor|Differentiation-stimulating factor|D factor|Interleukin 6 family cytokine|Melanoma-derived LPL inhibitor (MLPLI)
- Purity:98%
- Endotoxin level:Low
- Sequence:SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQLNGSANAL FILYYTAQGE PFPNNLDKLC GPNVTDFPPF HANGTEKAKL VELYRIVVYL GTSLGNITRD QKILNPSALS LHSKLNATAD ILRGLLSNVL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKK LGCQLLGKYK QIIAVLAQAF
- Source:E. coli
- Biological activity:Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.
- Molecular weight:19.7 kDa
- Shipping temperature:Ambient
- Cat. No.:76303-832
- Protein/peptide type:Recombinant
- Gene ID:3976
- Formulation:Lyophilized
- Conjugation:Unconjugated
- Species:Human
- Animal-free:Y
Spécifications
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Catalog #: CA21905-026
Supplier: Kimberly-Clark