Cysteinyl Leukotriene Express ELISA Kit, Cayman Chemical Company

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Competitive assay used for quantification of CysLT.

Detect all CysLTs (LTC₄, LTD₄, and LTE₄) in urine, tissue culture medium, and other sample matrices
Assay 24 samples in triplicate or 36 samples in duplicate
Measure CysLT levels down to 20 pg/ml
Read: Colorimetric at 405 to 420 nm

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase (5-LO) pathway in leukocytes. LTC₄, LTD₄, and LTE₄ are collectively referred to as cysteinyl leukotrienes (CysLTs).

LTC₄ and LTD₄ are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. The biological activity of LTE₄ is much lower in most systems studied, but its presence reflects the prior existence of LTC₄ and LTD₄.

CysLT Express ELISA Kit is a competitive assay that can be used for measurement of all three primary CysLTs in urine, culture media, and other sample matrices. This sensitive assay takes about three hours to complete.

Delivery: Kit contains antibody, tracer, buffer a concentrate; wash buffer concentrate, polysorbate 20, plate and cover sheet, Ellmans reagent.

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