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- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Rat
- Size:25 µg
- Storage conditions:Store vial at 4 °C prior to restoration. Dilute only prior to immediate use. Maintain sterility. This product DOES NOT contain preservative. DO NOT VORTEX. We recommend adding a carrier protein such as HSA or BSA to 0.1% (i.e. 1.0 mg/mL) . For best results aliquot contents and freeze at –20 °C or colder. Avoid cycles of freezing and thawing. Centrifuge vial before each opening to dislodge contents from the cap and to clarify if contents are not clear after standing at room temperature.
- Endotoxin content:Measured by LAL is 0.03 EUs/µg protein.
- Biological activity:Rat IL-17A is fully biologically active when compared to standards via dose-dependent induction of IL-6 production in cultured mouse NIH 3T3 fibroblasts. The ED50 for recombinant rat IL-17A in this assay was 0.44-0.66ng/ml.
- Gene ID:Q61453
- Reconstitution instructions:250 µL
- Protein synonyms:IL-17|IL-17A|CTLA-8|Interleukin-17A cytokine|Cytotoxic T-lymphocyte-associated antigen 8
- Protein/peptide name:Il17a
- Purity:>97%
- Formulation:Lyophilized
- Shipping temperature:Ambient
- Cat. no.:RL012-001-B32
- Supplier No.:012-001-B32
Rat IL- 17A (IL-17), also known as CTLA-8, is a proinflammatory cytokine member of a six-species family of proteins (IL-17A-17F). Rat IL-17A protein is a homodimer consisting of two 134 amino acids peptides. IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most strikingly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. There is 58% identity between the amino acid sequence of human and rat IL-17A. Recombinant rat IL-17A produced in E.coli is a non-glycosylated disulfide-joined homodimer having a molecular mass of 30.0 kDa.