6-keto Prostaglandin F1α ELISA Kit, Cayman Chemical Company

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For the quantification of 6-keto PGF_1α in various samples.

Detect 6-keto PGF_1α, a surrogate for prostacyclin synthesis in multiple sample types
Assay 24 samples in triplicate or 36 samples in duplicate
Measure 6-keto PGF_1α levels down to 6 pg/mL
Incubation: 18 hours | Development: 90 – 120 minutes | Read: Colorimetric at 405 – 420 nm

Prostacyclin is formed from arachidonic acid primarily by the vascular endothelium and renal cortex. It is a potent vasodilator and inhibitor of platelet aggregation. PGI₂ is non-enzymatically hydrated to 6-keto PGF_1α (t_½ = 2 – 3 minutes), and then quickly converted to the major metabolite, 2,3-dinor-6-keto PGF1α (t_½ = 30 minutes).

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