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- Conjugation:Unconjugated
- Protein/peptide type:Recombinant
- Source:NS0 cells
- Species:Human
- Size:100 µl
- Storage conditions:–78 °C
- Protein synonyms:MMP-10 recombinant|MMP-10|Matrix metalloproteinase 10
- UniProtKB:P09238
- Protein/peptide name:MMP-10
- Molecular weight:58 kDa
- Concentration:10 μg/mL
- Cat. no.:103010-388
- Supplier No.:AS-72067
Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. MMP-10 (stromelysin 2) is involved in several pathological conditions, such as cancer, arthritis and wound healing. MMP-10 is secreted as zymogen with a prodomain, a catalytic domain, a hinge region, and a hemopexin-like domain. It can activate other MMPs such as MMP-1, MMP-8 and degrade a variety of substrates, including gelatin, collagens III, IV and V, fibronectin, aggrecan
This recombinant human MMP-10 was expressed as a pro-enzyme enzyme from its DNA sequence7 transfected into a mouse myeloma cell line, NS0. The apparent Mr on SDS-PAGE is 58-kDa. Incubation with 1 mM APMA at 37°C for 1-2 hours will activate pro-MMP-10. Its activity can be measured by FRET peptides