Mouse Recombinant GDNF (from E. coli)
About this item
GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional murine GDNF ligand is a disulfide-linked homodimer consisting of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration. The calculated molecular weight of Recombinant Murine GDNF is 30.2 kDa.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.
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Product Details & Documents
GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional murine GDNF ligand is a disulfide-linked homodimer consisting of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration. The calculated molecular weight of Recombinant Murine GDNF is 30.2 kDa.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.
Specifications for Product Family
Specifications
Specifications
- Catalog No:
- 10771-110
- 10771-112
- 10771-114
- 10771-116
- 10771-118
- 10771-120
- 10771-122
- Protein/peptide name:
- GDNF
- GDNF
- GDNF
- GDNF
- GDNF
- GDNF
- GDNF
- Protein synonyms:
- Glial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)
- Glial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)
- Glial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)
- Glial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)
- Glial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)
- Glial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)
- Glial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)
- Protein/peptide type:
- Recombinant
- Recombinant
- Recombinant
- Recombinant
- Recombinant
- Recombinant
- Recombinant
- Protein Function:
- Cytokines and Growth Factors
- Cytokines and Growth Factors
- Cytokines and Growth Factors
- Cytokines and Growth Factors
- Cytokines and Growth Factors
- Cytokines and Growth Factors
- Cytokines and Growth Factors
- Species:
- Mouse
- Mouse
- Mouse
- Mouse
- Mouse
- Mouse
- Mouse
- Source:
- E. coli
- E. coli
- E. coli
- E. coli
- E. coli
- E. coli
- E. coli
- Conjugation:
- Unconjugated
- Unconjugated
- Unconjugated
- Unconjugated
- Unconjugated
- Unconjugated
- Unconjugated
- Gene ID:
- 14573 P48540
- 14573 P48540
- 14573 P48540
- 14573 P48540
- 14573 P48540
- 14573 P48540
- 14573 P48540
- Sequence:
- MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
- MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
- MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
- MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
- MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
- MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
- MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
- Protease-free:
- Y
- Y
- Y
- Y
- Y
- Y
- Y
- Endotoxin level:
- Low
- Low
- Low
- Low
- Low
- Low
- Low
- Endotoxin content:
- >0.1 ng/μg
- >0.1 ng/μg
- >0.1 ng/μg
- >0.1 ng/μg
- >0.1 ng/μg
- >0.1 ng/μg
- >0.1 ng/μg
- Biological activity:
- Biological Activity tests can vary. Please refer to the Product CoA for information.
- Biological Activity tests can vary. Please refer to the Product CoA for information.
- Biological Activity tests can vary. Please refer to the Product CoA for information.
- Biological Activity tests can vary. Please refer to the Product CoA for information.
- Biological Activity tests can vary. Please refer to the Product CoA for information.
- Biological Activity tests can vary. Please refer to the Product CoA for information.
- Biological Activity tests can vary. Please refer to the Product CoA for information.
- Purity:
- 0.98
- 0.98
- 0.98
- 0.98
- 0.98
- 0.98
- 0.98
- Form:
- Lyophilized
- Lyophilized
- Lyophilized
- Lyophilized
- Lyophilized
- Lyophilized
- Lyophilized
- Formulation:
- Formulation can vary. Please refer to product CoA for information.
- Formulation can vary. Please refer to product CoA for information.
- Formulation can vary. Please refer to product CoA for information.
- Formulation can vary. Please refer to product CoA for information.
- Formulation can vary. Please refer to product CoA for information.
- Formulation can vary. Please refer to product CoA for information.
- Formulation can vary. Please refer to product CoA for information.
- Molecular weight:
- 30.2 kDa
- 30.2 kDa
- 30.2 kDa
- 30.2 kDa
- 30.2 kDa
- 30.2 kDa
- 30.2 kDa
- Reconstitution instructions:
- Reconstitution instructions can vary. Please refer to the product CoA for info.
- Reconstitution instructions can vary. Please refer to the product CoA for info.
- Reconstitution instructions can vary. Please refer to the product CoA for info.
- Reconstitution instructions can vary. Please refer to the product CoA for info.
- Reconstitution instructions can vary. Please refer to the product CoA for info.
- Reconstitution instructions can vary. Please refer to the product CoA for info.
- Reconstitution instructions can vary. Please refer to the product CoA for info.
- Storage conditions:
- Store at –20 °C prior to reconstitution.
- Store at –20 °C prior to reconstitution.
- Store at –20 °C prior to reconstitution.
- Store at –20 °C prior to reconstitution.
- Store at –20 °C prior to reconstitution.
- Store at –20 °C prior to reconstitution.
- Store at –20 °C prior to reconstitution.
- Shipping temperature:
- Ambient
- Ambient
- Ambient
- Ambient
- Ambient
- Ambient
- Ambient
Specifications
Product Family Options
Product Information
- TailleOriginAvailabilityPrice
- Supplier Number: 450-44-2UGItem requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.10771-110Protein/peptide nameGDNFProtein synonymsGlial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)Protein/peptide typeRecombinantProtein FunctionCytokines and Growth FactorsSpeciesMouseSourceE. coliConjugationUnconjugatedGene ID14573 P48540SequenceMSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCIProtease-freeYEndotoxin levelLowEndotoxin content>0.1 ng/μgBiological activityBiological Activity tests can vary. Please refer to the Product CoA for information.Purity0.98FormLyophilizedFormulationFormulation can vary. Please refer to product CoA for information.Molecular weight30.2 kDaReconstitution instructionsReconstitution instructions can vary. Please refer to the product CoA for info.Storage conditionsStore at –20 °C prior to reconstitution.Shipping temperatureAmbient - Supplier Number: 450-44-10UGItem requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.10771-112Protein/peptide nameGDNFProtein synonymsGlial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)Protein/peptide typeRecombinantProtein FunctionCytokines and Growth FactorsSpeciesMouseSourceE. coliConjugationUnconjugatedGene ID14573 P48540SequenceMSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCIProtease-freeYEndotoxin levelLowEndotoxin content>0.1 ng/μgBiological activityBiological Activity tests can vary. Please refer to the Product CoA for information.Purity0.98FormLyophilizedFormulationFormulation can vary. Please refer to product CoA for information.Molecular weight30.2 kDaReconstitution instructionsReconstitution instructions can vary. Please refer to the product CoA for info.Storage conditionsStore at –20 °C prior to reconstitution.Shipping temperatureAmbient - Supplier Number: 450-44-50UGItem requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.10771-114Protein/peptide nameGDNFProtein synonymsGlial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)Protein/peptide typeRecombinantProtein FunctionCytokines and Growth FactorsSpeciesMouseSourceE. coliConjugationUnconjugatedGene ID14573 P48540SequenceMSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCIProtease-freeYEndotoxin levelLowEndotoxin content>0.1 ng/μgBiological activityBiological Activity tests can vary. Please refer to the Product CoA for information.Purity0.98FormLyophilizedFormulationFormulation can vary. Please refer to product CoA for information.Molecular weight30.2 kDaReconstitution instructionsReconstitution instructions can vary. Please refer to the product CoA for info.Storage conditionsStore at –20 °C prior to reconstitution.Shipping temperatureAmbient - Supplier Number: 450-44-100UGItem requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.10771-116Protein/peptide nameGDNFProtein synonymsGlial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)Protein/peptide typeRecombinantProtein FunctionCytokines and Growth FactorsSpeciesMouseSourceE. coliConjugationUnconjugatedGene ID14573 P48540SequenceMSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCIProtease-freeYEndotoxin levelLowEndotoxin content>0.1 ng/μgBiological activityBiological Activity tests can vary. Please refer to the Product CoA for information.Purity0.98FormLyophilizedFormulationFormulation can vary. Please refer to product CoA for information.Molecular weight30.2 kDaReconstitution instructionsReconstitution instructions can vary. Please refer to the product CoA for info.Storage conditionsStore at –20 °C prior to reconstitution.Shipping temperatureAmbient - Supplier Number: 450-44-250UGItem requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.10771-118Protein/peptide nameGDNFProtein synonymsGlial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)Protein/peptide typeRecombinantProtein FunctionCytokines and Growth FactorsSpeciesMouseSourceE. coliConjugationUnconjugatedGene ID14573 P48540SequenceMSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCIProtease-freeYEndotoxin levelLowEndotoxin content>0.1 ng/μgBiological activityBiological Activity tests can vary. Please refer to the Product CoA for information.Purity0.98FormLyophilizedFormulationFormulation can vary. Please refer to product CoA for information.Molecular weight30.2 kDaReconstitution instructionsReconstitution instructions can vary. Please refer to the product CoA for info.Storage conditionsStore at –20 °C prior to reconstitution.Shipping temperatureAmbient - Supplier Number: 450-44-500UGItem requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.10771-120Protein/peptide nameGDNFProtein synonymsGlial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)Protein/peptide typeRecombinantProtein FunctionCytokines and Growth FactorsSpeciesMouseSourceE. coliConjugationUnconjugatedGene ID14573 P48540SequenceMSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCIProtease-freeYEndotoxin levelLowEndotoxin content>0.1 ng/μgBiological activityBiological Activity tests can vary. Please refer to the Product CoA for information.Purity0.98FormLyophilizedFormulationFormulation can vary. Please refer to product CoA for information.Molecular weight30.2 kDaReconstitution instructionsReconstitution instructions can vary. Please refer to the product CoA for info.Storage conditionsStore at –20 °C prior to reconstitution.Shipping temperatureAmbient - Supplier Number: 450-44-1MGItem requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.Specifications:
More
Specifications
Cat. No.10771-122Protein/peptide nameGDNFProtein synonymsGlial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)Protein/peptide typeRecombinantProtein FunctionCytokines and Growth FactorsSpeciesMouseSourceE. coliConjugationUnconjugatedGene ID14573 P48540SequenceMSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCIProtease-freeYEndotoxin levelLowEndotoxin content>0.1 ng/μgBiological activityBiological Activity tests can vary. Please refer to the Product CoA for information.Purity0.98FormLyophilizedFormulationFormulation can vary. Please refer to product CoA for information.Molecular weight30.2 kDaReconstitution instructionsReconstitution instructions can vary. Please refer to the product CoA for info.Storage conditionsStore at –20 °C prior to reconstitution.Shipping temperatureAmbient
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