Human Recombinant Heregulinbeta-1 (from E. coli)

Human Recombinant Heregulinbeta-1 (from <i>E. coli</i>)

Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4).

Recombinant Human Heregulinβ-1 is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinβ-1 (65 amino acid residues)

To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-β1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF).

: For research use only. Not for use in diagnostic or therapeutic procedures.

Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4).

Recombinant Human Heregulinβ-1 is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinβ-1 (65 amino acid residues)

: For research use only. Not for use in diagnostic or therapeutic procedures.

Catalog No:
10770-630
10770-632
10770-634
10770-636
10770-638
10770-640

Protein/peptide name:
Heregulinbeta-1
Heregulinbeta-1
Heregulinbeta-1
Heregulinbeta-1
Heregulinbeta-1
Heregulinbeta-1

Protein synonyms:
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)

Protein/peptide type:
Recombinant
Recombinant
Recombinant
Recombinant
Recombinant
Recombinant

Protein Function:
Cytokines and Growth Factors
Cytokines and Growth Factors
Cytokines and Growth Factors
Cytokines and Growth Factors
Cytokines and Growth Factors
Cytokines and Growth Factors

Species:
Human
Human
Human
Human
Human
Human

Source:
E. coli
E. coli
E. coli
E. coli
E. coli
E. coli

Conjugation:
Unconjugated
Unconjugated
Unconjugated
Unconjugated
Unconjugated
Unconjugated

Gene ID:
3084 Q02297
3084 Q02297
3084 Q02297
3084 Q02297
3084 Q02297
3084 Q02297

Sequence:
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE

Protease-free:
Y
Y
Y
Y
Y
Y

Endotoxin level:
Low
Low
Low
Low
Low
Low

Endotoxin content:
>0.1 ng/μg
>0.1 ng/μg
>0.1 ng/μg
>0.1 ng/μg
>0.1 ng/μg
>0.1 ng/μg

Biological activity:
Biological Activity tests can vary. Please refer to the Product CoA for information.
Biological Activity tests can vary. Please refer to the Product CoA for information.
Biological Activity tests can vary. Please refer to the Product CoA for information.
Biological Activity tests can vary. Please refer to the Product CoA for information.
Biological Activity tests can vary. Please refer to the Product CoA for information.
Biological Activity tests can vary. Please refer to the Product CoA for information.

Purity:
0.98
0.98
0.98
0.98
0.98
0.98

Form:
Lyophilized
Lyophilized
Lyophilized
Lyophilized
Lyophilized
Lyophilized

Formulation:
Formulation can vary. Please refer to product CoA for information.
Formulation can vary. Please refer to product CoA for information.
Formulation can vary. Please refer to product CoA for information.
Formulation can vary. Please refer to product CoA for information.
Formulation can vary. Please refer to product CoA for information.
Formulation can vary. Please refer to product CoA for information.

Molecular weight:
7.5 kDa
7.5 kDa
7.5 kDa
7.5 kDa
7.5 kDa
7.5 kDa

Reconstitution instructions:
Reconstitution instructions can vary. Please refer to the product CoA for info.
Reconstitution instructions can vary. Please refer to the product CoA for info.
Reconstitution instructions can vary. Please refer to the product CoA for info.
Reconstitution instructions can vary. Please refer to the product CoA for info.
Reconstitution instructions can vary. Please refer to the product CoA for info.
Reconstitution instructions can vary. Please refer to the product CoA for info.

Storage conditions:
Store at –20 °C prior to reconstitution.
Store at –20 °C prior to reconstitution.
Store at –20 °C prior to reconstitution.
Store at –20 °C prior to reconstitution.
Store at –20 °C prior to reconstitution.
Store at –20 °C prior to reconstitution.

Shipping temperature:
Ambient
Ambient
Ambient
Ambient
Ambient
Ambient

Product Family Options

Taille
Origin
10770-630
10 μg
US

Each (10µG)
Each (10µG) - 243,58 $
243,58 $
Each (10µG)
243,58 $

: 100-03-10UG

Specifications
Cat. No.
10770-630
Protein/peptide name
Heregulinbeta-1
Protein synonyms
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
Protein/peptide type
Recombinant
Protein Function
Cytokines and Growth Factors
Species
Human
Source
E. coli
Conjugation
Unconjugated
Gene ID
3084 Q02297
Sequence
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Protease-free
Y
Endotoxin level
Low
Endotoxin content
>0.1 ng/μg
Biological activity
Biological Activity tests can vary. Please refer to the Product CoA for information.
Purity
0.98
Form
Lyophilized
Formulation
Formulation can vary. Please refer to product CoA for information.
Molecular weight
7.5 kDa
Reconstitution instructions
Reconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditions
Store at –20 °C prior to reconstitution.
Shipping temperature
Ambient
10770-632
50 μg
US

Each (50µG)
Each (50µG) - 591,67 $
591,67 $
Each (50µG)
591,67 $

: 100-03-50UG

Specifications
Cat. No.
10770-632
Protein/peptide name
Heregulinbeta-1
Protein synonyms
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
Protein/peptide type
Recombinant
Protein Function
Cytokines and Growth Factors
Species
Human
Source
E. coli
Conjugation
Unconjugated
Gene ID
3084 Q02297
Sequence
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Protease-free
Y
Endotoxin level
Low
Endotoxin content
>0.1 ng/μg
Biological activity
Biological Activity tests can vary. Please refer to the Product CoA for information.
Purity
0.98
Form
Lyophilized
Formulation
Formulation can vary. Please refer to product CoA for information.
Molecular weight
7.5 kDa
Reconstitution instructions
Reconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditions
Store at –20 °C prior to reconstitution.
Shipping temperature
Ambient
10770-634
100 μg
US

Each (100µG)
Each (100µG) - 954,95 $
954,95 $
Each (100µG)
954,95 $

: 100-03-100UG

Specifications
Cat. No.
10770-634
Protein/peptide name
Heregulinbeta-1
Protein synonyms
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
Protein/peptide type
Recombinant
Protein Function
Cytokines and Growth Factors
Species
Human
Source
E. coli
Conjugation
Unconjugated
Gene ID
3084 Q02297
Sequence
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Protease-free
Y
Endotoxin level
Low
Endotoxin content
>0.1 ng/μg
Biological activity
Biological Activity tests can vary. Please refer to the Product CoA for information.
Purity
0.98
Form
Lyophilized
Formulation
Formulation can vary. Please refer to product CoA for information.
Molecular weight
7.5 kDa
Reconstitution instructions
Reconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditions
Store at –20 °C prior to reconstitution.
Shipping temperature
Ambient
10770-636
250 μg
US

Each (250µG)
Each (250µG) - 1 591,63 $
1 591,63 $
Each (250µG)
1 591,63 $

: 100-03-250UG

Specifications
Cat. No.
10770-636
Protein/peptide name
Heregulinbeta-1
Protein synonyms
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
Protein/peptide type
Recombinant
Protein Function
Cytokines and Growth Factors
Species
Human
Source
E. coli
Conjugation
Unconjugated
Gene ID
3084 Q02297
Sequence
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Protease-free
Y
Endotoxin level
Low
Endotoxin content
>0.1 ng/μg
Biological activity
Biological Activity tests can vary. Please refer to the Product CoA for information.
Purity
0.98
Form
Lyophilized
Formulation
Formulation can vary. Please refer to product CoA for information.
Molecular weight
7.5 kDa
Reconstitution instructions
Reconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditions
Store at –20 °C prior to reconstitution.
Shipping temperature
Ambient
10770-638
500 μg
US

Each (500µG)
Each (500µG) - 2 518,69 $
2 518,69 $
Each (500µG)
2 518,69 $

: 100-03-500UG

Specifications
Cat. No.
10770-638
Protein/peptide name
Heregulinbeta-1
Protein synonyms
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
Protein/peptide type
Recombinant
Protein Function
Cytokines and Growth Factors
Species
Human
Source
E. coli
Conjugation
Unconjugated
Gene ID
3084 Q02297
Sequence
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Protease-free
Y
Endotoxin level
Low
Endotoxin content
>0.1 ng/μg
Biological activity
Biological Activity tests can vary. Please refer to the Product CoA for information.
Purity
0.98
Form
Lyophilized
Formulation
Formulation can vary. Please refer to product CoA for information.
Molecular weight
7.5 kDa
Reconstitution instructions
Reconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditions
Store at –20 °C prior to reconstitution.
Shipping temperature
Ambient
10770-640
1 mg
US

Each (1mg)
Each (1mg) - 4 550,16 $
4 550,16 $
Each (1mg)
4 550,16 $

: 100-03-1MG

Specifications
Cat. No.
10770-640
Protein/peptide name
Heregulinbeta-1
Protein synonyms
HRG1-β1|glial growth factor|ARIA (Acetylcholine Receptor Inducing Activity)|Breast cancer cell differentiation factor p45|HRG|Neuregulin1 (NRG1-β1)|Neu differentiation factor (rat)
Protein/peptide type
Recombinant
Protein Function
Cytokines and Growth Factors
Species
Human
Source
E. coli
Conjugation
Unconjugated
Gene ID
3084 Q02297
Sequence
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Protease-free
Y
Endotoxin level
Low
Endotoxin content
>0.1 ng/μg
Biological activity
Biological Activity tests can vary. Please refer to the Product CoA for information.
Purity
0.98
Form
Lyophilized
Formulation
Formulation can vary. Please refer to product CoA for information.
Molecular weight
7.5 kDa
Reconstitution instructions
Reconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditions
Store at –20 °C prior to reconstitution.
Shipping temperature
Ambient