Mca-Amyloid beta/A4 Protein Precursor₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide Trifluoroacetate

This fluorescent (FRET) peptide substrate contains the wild-type amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVKMDAEFRK(Dnp)RR- amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo. See also L-1905.

CAS No.:
1802078-33-6
Storage conditions:
–20 ± 5 °C
MDL No.:
MFCD18782559
Protein/peptide name:
Mca-Amyloid beta/A4 Protein Precursor₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide Trifluoroacetate
Molecular weight:
2033.21
Sequence:
Mca-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH₂
Molecular formula:
C₈₇H₁₂₉N₂₇O₂₈S