Cyclo(-Phe-Pro)
À propos de cet article
Also known as dioxopiperazines, piperazine-2,5-diones or DKPs. Diketopiperazines may occur as by-products during peptide synthesis or during the degradation of peptides. These cyclic dipeptides have been detected as taste-modulating compounds in food, they often show biological activity. DKPs are valuable chiral synthons, employed e.g. in Schöllkopf's versatile bislactim ether approach. They also have found use as catalysts for enantioselective synthesis, e.g. in the asymmetric Strecker reaction. See also the TRH metabolite cyclo(-His-Pro), G-1745, and cyclo(-Asp-Phe), G-1695, the major degradation product of aspartame.
Cain et al. obtained an array of small molecule peptide mimetics targeting the melanocortin receptors from this diketopiperazine. Brauns et al. demonstrated that cyclo(Phe-Pro) inhibits the growth of HT-29, MCF-7 and HeLa cells and induces apoptosis in HT-29 colon cancer cells.
2 Options Available Below
- L'article nécessite un contrôle de la température pour le stockage et la livraison avec des frais supplémentaires. Il n'est pas éligible au retour pour des raisons de sécurité et de qualité. Tenez compte des exigences avant d'acheter.
- Return Policy
Product Details & Documents
Also known as dioxopiperazines, piperazine-2,5-diones or DKPs. Diketopiperazines may occur as by-products during peptide synthesis or during the degradation of peptides. These cyclic dipeptides have been detected as taste-modulating compounds in food, they often show biological activity. DKPs are valuable chiral synthons, employed e.g. in Schöllkopf's versatile bislactim ether approach. They also have found use as catalysts for enantioselective synthesis, e.g. in the asymmetric Strecker reaction. See also the TRH metabolite cyclo(-His-Pro), G-1745, and cyclo(-Asp-Phe), G-1695, the major degradation product of aspartame.
Cain et al. obtained an array of small molecule peptide mimetics targeting the melanocortin receptors from this diketopiperazine. Brauns et al. demonstrated that cyclo(Phe-Pro) inhibits the growth of HT-29, MCF-7 and HeLa cells and induces apoptosis in HT-29 colon cancer cells.
Specifications for Product Family
Spécifications
Spécifications
- Catalog No:
- G-4720.0250BA
- G-4720.1000BA
- Protein/peptide name:
- Cyclo(-Phe-Pro)
- Cyclo(-Phe-Pro)
- CAS No.:
- 3705-26-8
- 3705-26-8
- MDL No.:
- MFCD00038604
- MFCD00038604
- Sequence:
- Cyclo(-Phe-Pro)
- Cyclo(-Phe-Pro)
- Molecular weight:
- 244.29
- 244.29
- Molecular formula:
- C₁₄H₁₆N₂O₂
- C₁₄H₁₆N₂O₂
- Storage conditions:
- –20 ± 5 °C
- –20 ± 5 °C
Spécifications
Product Family Options
Informations sur le produit
- TailleAvailabilityPrice
- Supplier Number: 4029456.0250L'article nécessite un contrôle de la température pour le stockage et la livraison avec des frais supplémentaires. Il n'est pas éligible au retour pour des raisons de sécurité et de qualité. Tenez compte des exigences avant d'acheter.Spécifications:
More
Specifications
Cat. No.G-4720.0250BAProtein/peptide nameCyclo(-Phe-Pro)CAS No.3705-26-8MDL No.MFCD00038604SequenceCyclo(-Phe-Pro)Molecular weight244.29Molecular formulaC₁₄H₁₆N₂O₂Storage conditions–20 ± 5 °C - Supplier Number: 4029456.1000L'article nécessite un contrôle de la température pour le stockage et la livraison avec des frais supplémentaires. Il n'est pas éligible au retour pour des raisons de sécurité et de qualité. Tenez compte des exigences avant d'acheter.Spécifications:
More
Specifications
Cat. No.G-4720.1000BAProtein/peptide nameCyclo(-Phe-Pro)CAS No.3705-26-8MDL No.MFCD00038604SequenceCyclo(-Phe-Pro)Molecular weight244.29Molecular formulaC₁₄H₁₆N₂O₂Storage conditions–20 ± 5 °C
Recommendations will be personalized based on your shopping preferences only if you have given your consent by enabling "Enhance my Shopping Experience" on the "Personal Info page".
Otherwise, you will receive generic recommendations.
Catalog #: CA21905-026
Supplier: Kimberly-Clark