EX 527
EX 527
Supplier: Abcam
Selective, cell-permeable SIRT1 Inhibitor. (IC₅₀= 98 nM, 19.6, 48.7 and > 100 μM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Shows no effect at other HDACs or SIRTs. Enhances p53 acetylation in response to DNA damaging agents.
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EX 527 ≥95%
Supplier: Enzo Life Sciences
Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC50=98nM in vivo / IC50=38nM in vitro; compared to hSIRT2: IC50=19µM and hSIRT3: IC50=48µM) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC50>100µg). Inhibits the deacetylation of p53 (IC50=1µM).
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EX 527
Supplier: Thermo Scientific Chemicals
A potent and selective inhibitor of the SIRT1 class III histone deacetylase enzyme
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Catalog #: CA21905-026
Supplier: Kimberly-Clark