59 Results for: "Sugars, Amino Acids & Nucleotides"

Supplier: Prosci

SLC35D3 Antibody: The solute carrier family SLC35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The novel protein SLC35D3 is highly homologous to SLC35D1 and SLC35D2, both of which transport UDP-glucuronic acid and UDP-N-acetylgalactosamine, suggesting that SLC35D3 is also involved in the transport of nucleotide sugars. It has been suggested that SLC35D3 regulates platelet dense granules, lysosome-related organelles which contain high concentrations of several biologically important low molecular weight molecules necessary for normal blood homeostasis.

Supplier: Thermo Scientific

This antibody is predicted to react with mouse and rat based on sequence homology. This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine , and insulin resistance.

Supplier: Prosci

SLC35D2 Antibody: The solute carrier family SLC35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident SLC family member SLC35D2 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. Its overexpression in transfected cells modulated cell surface heparin sulfate expression, suggesting that SLC35D2 is involved in heparin sulfate synthesis. SLC35D2-overexpressing cells also showed increased constitutive and hypotonic stress-stimulated release of UDP-GlcNAc, suggesting that SLC35D2 may be involved in UDP-sugar release and cell signaling.

Supplier: Prosci

Slc35D1 Antibody: The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.

Supplier: Prosci

Slc35D1 Antibody: The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.

Supplier: Prosci

Slc35D1 Antibody: The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.

Supplier: Prosci

Slc35D1 Antibody: The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.

Supplier: Thermo Scientific Chemicals

D-allo-Threonine 99%

Supplier: Thermo Scientific Chemicals

D-(-)-2-Cyclohexylglycine, 95%

Supplier: Thermo Scientific Chemicals

d-Benzyloxycarbonyl-L-ornithine, 98%

Supplier: Thermo Scientific Chemicals

L-Phenylalaninamide, 98%

Supplier: Thermo Scientific Chemicals

DL-Tryptophanamide, 98%

Supplier: Thermo Scientific Chemicals

3-Nitro-D-phenylalanine, 95%

Supplier: Thermo Scientific Chemicals

3-(2-Naphthyl)-D-alanine, 95%

Supplier: Thermo Scientific Chemicals

MDL: MFCD00064315 Beilstein Registry No.: 4673585 Optical Rotation: -39°C (c=5 in water)

Supplier: Thermo Scientific Chemicals

3-(2-Thienyl)-L-alanine, 95%

Supplier: Thermo Scientific Chemicals

DL-Glutamic acid, 95%

Supplier: Thermo Scientific Chemicals

2-Bromo-L-phenylalanine, 95%

Supplier: Thermo Scientific Chemicals

3-(4-Thiazolyl)-L-alanine, 95%

Supplier: Thermo Scientific Chemicals

3-(3-Pyridyl)-L-alanine, 98%

Supplier: Thermo Scientific Chemicals

N-Formyl-L-methionine, 95%

Supplier: Thermo Scientific Chemicals

D-Tyrosine tert-butyl ester, 98%

Supplier: Thermo Scientific Chemicals

DL-tert-Leucine, 95%

Supplier: Thermo Scientific Chemicals

(-)-S-Trityl-D-cysteine, 98%

Supplier: Thermo Scientific Chemicals

3-(3-Pyridyl)-D-alanine, 95%

Supplier: Thermo Scientific Chemicals

1-Trityl-L-histidine, 98%

Supplier: Thermo Scientific Chemicals

N-Acetyl-L-glutamic acid 5-tert-butyl ester, 95%

Supplier: Thermo Scientific Chemicals

d-Boc-N^a-Fmoc-D-ornithine, 95%

Supplier: Thermo Scientific Chemicals

L-Tryptophanol, 97%

Supplier: Thermo Scientific Chemicals

N-Fmoc-L-methionine sulfoxide, 98%