977 Results for: "Stemcell Technologies"

Supplier: Stemcell Technologies

Rat monoclonal antibody against mouse CD127, PE-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal antibody against human, rhesus CD80 (B7-1), APC-conjugated.

Supplier: Stemcell Technologies

Rat monoclonal antibody against mouse CD3, unconjugated.

Supplier: Stemcell Technologies

Anti-Adherence Rinsing Solution is a surfactant solution for pre-treating cultureware to reduce surface tension and prevent cell adhesion. It can be used with plates, flasks, pipettes, strainers and other cultureware.

Supplier: Stemcell Technologies

Immunodensity isolation of untouched CD4+ T cells.

Supplier: Stemcell Technologies

Human T cell activation and expansion reagent. 5×2 ml vials.

Supplier: Stemcell Technologies

Feeder-free, animal component-free culture medium for maintenance of human ES and iPS cells.

Supplier: Stemcell Technologies

Defined, serum-free, xeno-free medium for pluripotent stem cells.

Supplier: Stemcell Technologies

Immunomagnetic positive selection of human cells labeled with APC-conjugated antibodies.

Supplier: Stemcell Technologies

Column-free immunomagnetic positive selection of human CD19+ cells for HLA analysis

Supplier: Stemcell Technologies

Immunodensity isolation of untouched T cells.

Supplier: Stemcell Technologies

Rat monoclonal antibody against mouse CD127, APC-conjugated.

Supplier: Stemcell Technologies

Rat monoclonal antibody against mouse, hamster CD4, PerCP-Cy5.5-conjugated.

Supplier: Stemcell Technologies

Rat monoclonal antibody against mouse, hamster CD4, FITC-conjugated.

Supplier: Stemcell Technologies

Rat monoclonal antibody against mouse CD86 (B7-2), APC-conjugated.

Supplier: Stemcell Technologies

Hamster (Syrian) monoclonal antibody against mouse KLRG1, PE-conjugated.

Supplier: Stemcell Technologies

For detection and measurement of human pan interferon-alpha.

Supplier: Stemcell Technologies

Integrated workflow containing tools to isolate and expand erythroid progenitor cells from peripheral blood and their subsequent reprogramming to iPS cells.

Supplier: Stemcell Technologies

For digestion of native collagen fibrils.

Supplier: Stemcell Technologies

Serum-free supplement for the derivation and expansion of human skeletal muscle progenitor cells (myoblasts).

Supplier: Stemcell Technologies

Immunodensity isolation of untouched plasma cells for multiple myeloma research.

Supplier: Stemcell Technologies

Immunomagnetic positive selection of mouse regulatory T cells.

Supplier: Stemcell Technologies

Interleukin 3 (IL-3) is a species-specific pleiotropic cytokine that promotes the survival and proliferation of pluripotent hematopoietic stem cells and lineage-committed progenitor cells and their differentiation into mature cells of most lineages, including mast cells, basophils, neutrophils, eosinophils, macrophages, dendritic cells, erythrocytes, and megakaryocytes (Fung et al.; Metcalf et al.; Broughton et al.). IL-3 is produced by activated T cells, and has a physiological role in inflammation and allergies by promoting the secretion of inflammatory mediators such as histamine, IL-4, and IL-6 by mast cells, basophils and eosinophils. The mouse IL-3 receptor consists of a unique alpha-subunit (CD123) and two beta subunits, one specific for IL-3 (βIL-3), the other shared with the receptors for IL-5 and GM-CSF (beta common chain, βc or CD131). IL-3 binding to heterodimeric receptors containing the alpha subunit and one of either beta subunits activates JAK/STAT, MAPK, and PI3K signaling pathways (Scott and Begley).

Supplier: Stemcell Technologies

Interleukin 4 (IL-4) is a type I cytokine produced by Th2 T cells, NK T cells, γ/δ T cells, eosinophils, mast cells, and activated basophils. IL-4 receptors are present on a number of cells, including hematopoietic, endothelial, epithelial, muscle, and brain tissues. IL-4 receptor engagement initiates signaling through the JAK/STAT pathway, and leads to the activation of PI3K and Ras/MAPK pathways (Nelms et al.). IL-4 plays a key role in immunoglobulin class switching in B cells and in regulating the differentiation of naïve T cells into T helper 2 (Th2) cells, while inhibiting Th1 differentiation. IL-4 acts together with tumor necrosis factor to stimulate expression of adhesion molecules on vascular endothelial cells and to downregulate expression of E-selectin, thus recruiting T cells and eosinophils to the site of inflammation (Nelms et al.).

Supplier: Stemcell Technologies

Epidermal growth factor (EGF) is characterized by high affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter and Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright et al.). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds and Weiss).

Supplier: Stemcell Technologies

Immunomagnetic enrichment of untouched human hematopoietic progenitor cells.

Supplier: Stemcell Technologies

Mouse monoclonal IgM antibody against human, mouse, rat SSEA-1 (CD15), unconjugated.

Supplier: Stemcell Technologies

Rabbit polyclonal IgG antibody against mouse Ym1, unconjugated.

Supplier: Stemcell Technologies

Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf and Nicola). G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit et al.), the activation of metalloproteases that cleave VCAM-1 (Levesque et al.), and the release of norepinephrine from the sympathetic nervous system (Katayama et al.), leading to the release or mobilization of hematopoietic stem cells from the bone marrow into the periphery. The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways. This product is animal component-free.

Supplier: Stemcell Technologies

Fibroblast growth factor 7 (FGF-7) is a member of the FGF family, and acts exclusively through a subset of FGF receptor isoforms expressed predominantly by epithelial cells (Finch and Rubin). FGF-7 seems to act specifically on epithelial cells and stimulates proliferation, migration, and differentiation of these cells, and also participates in epithelial protection and repair both in vitro and in vivo (Finch and Rubin; Werner). In contrast, FGF-7 is produced solely by cells of mesenchymal origin, and functions as a paracrine mediator of mesenchymal-epithelial communication (Rubin et al.). FGF-7 has also been shown to supplement several wound-healing properties of bioengineered skin (Erdag et al.) and to induce autophagy in human keratinocytes (Belleudi et al.). Additionally, FGF-7 has a role in pluripotent stem cell differentiation to endodermal pancreatic-like insulin-producing cells and thymic epithelial cells (Inami et al.; Niu et al.).