977 Results for: "Stemcell Technologies"

Supplier: Stemcell Technologies

The RoboSep™ Tip head polishing compound is a cleaning/polishing solution designed to remove residue build-up which may accumulate over time, thus improving the tip contact surface condition for pick up/stripping of disposable RoboSep™ tips.

Supplier: Stemcell Technologies

A member of the pentraxin family of proteins, C-reactive protein (CRP) plays important roles in host defenses, including regulating complement activation in vivo (Sjoberg et al.), decreasing nitric oxide production, and inhibiting angiogenesis in vitro (Verma et al., 2002). At specific concentrations, CRP directly inhibits endothelial progenitor cell (EPC) differentiation, survival, and function, and is thus implicated in the development of cardiovascular diseases (Verma et al., 2004). CRP is primarily synthesized by liver hepatocytes, but also by other immune cells, such as macrophages and lymphocytes (Sproston and Ashworth). The expression of this acute-phase protein is induced by IL-6 and IL-1 secretion of macrophages and T-cells during inflammation. For consistency and reproducibility across your applications, C-reactive protein from STEMCELL comes lyophilized with ≥ 87% purity, and endotoxin levels are verified to be ≤1.0 EU/μg protein.

Supplier: Stemcell Technologies

Methylcellulose-based medium with recombinant cytokines (without EPO) for human cells. 1×100 ml bottle.

Supplier: Stemcell Technologies

Kit for enzymatic dissociation of adult mouse and rat CNS tissue.

Supplier: Stemcell Technologies

Animal component-free medium for the differentiation of MSCs into chondrocytes.

Supplier: Stemcell Technologies

Immunomagnetic isolation of untouched human NK cells.

Supplier: Stemcell Technologies

Isolate untouched and highly purified CD8+ T cells from mouse splenocytes by immunomagnetic negative selection. When using single-cell suspensions from other tissue types, this kit may require optimization.

Supplier: Stemcell Technologies

Defined, animal component-free medium for differentiation of human ES and iPS cells to multiple lineages.

Supplier: Stemcell Technologies

Immunodensity isolation of untouched myeloid cells for lineage-specific chimerism analysis.

Supplier: Stemcell Technologies

Immunodensity depletion of granulocytes.

Supplier: Stemcell Technologies

Fibroblast growth factor 8A (FGF-8A) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. FGF-8A binds the FGF receptor (FGFR) and activates Ras/MAPK signaling (Hulstrand and Houston). The FGF family possesses broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and is involved in a variety of biological processes, including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). FGF-8 RNA is spliced to produce 4 protein isoforms in humans: FGF-8A, FGF-8B, FGF-8E, and FGF-8F. The functional differences are not fully understood; however, studies in zebrafish and Xenopus show that FGF-8A is required for endoderm morphogenesis and neurogenesis (Choe and Crump; Hulstrand and Houston).

Supplier: Stemcell Technologies

For digestion of native collagen fibrils.

Supplier: Stemcell Technologies

For characterization of human MSCs and their differentiation to chondrogenic, adipogenic, or osteogenic lineages.

Supplier: Stemcell Technologies

Purified human vitronectin solution for tissue engineering research and cell culture - 0.2 ml.

Supplier: Stemcell Technologies

Amphiregulin is a member of the epidermal growth factor (EGF) family. It binds to several receptors including EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3, and HER4/ErbB4, which activates Ras/Raf/MAPK and PI3K/AKT pathways. This results in cell proliferation, apoptosis resistance, and invasive behaviour (Normanno et al.). The expression of amphiregulin is induced by tissue injury and inflammation. Amphiregulin promotes mammary development, trophoblast growth, lung and kidney branching morphogenesis, and keratinocyte proliferation. It stimulates the growth of most cell types, including normal and transformed mammary epithelial cells, and malignant cells of the colon, prostate, cervix, and pancreas (Berasain and Avila).

Supplier: Stemcell Technologies

Hamster (Armenian) monoclonal antibody against mouse CD69, PE-Cy7-conjugated.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, chimpanzee CD73, unconjugated.

Supplier: Stemcell Technologies

Rat (WI) monoclonal IgG2b antibody against mouse TER119.

Supplier: Stemcell Technologies

A cytokine belonging to the type 1 interferon family, Interferon beta (IFN beta) binds IFN alpha/beta receptors (IFNAR) that activate tyrosine kinases and initiate the interferon-induced Jak-STAT signaling pathway, which modulates many key immune processes (Smieja et al.). In an experimental model involving cardiac fibroblasts isolated from rats, IFN beta was found to induce both pro- and anti-inflammatory cytokines production by activating different STAT proteins (Bolivar et al.). The anti-inflammatory effects of IFN beta have been studied in the context of autoimmune disorders, and there are currently multiple approved IFN beta drugs for treatment of relapsing forms of multiple sclerosis (Filipi and Jack). IFN beta is produced by immune cells, including macrophages, and non-immune cells, such as fibroblasts and epithelial cells (Ivashkiv and Donalin). The crystal structure of IFN beta shares characteristics with other type I interferons. It comprises five alpha-helices with four of them forming a helix bundle, and one long and three shorter loops connecting the helices (Karpusas et al.). For consistency and reproducibility across your applications, interferon alpha 1 from STEMCELL comes lyophilized with ≥ 87% purity, specific activity EC50 ≤18 pg/mL, and LAL analysis verification ensuring endotoxin levels are ≤1.0 EU/μg protein.

Supplier: Stemcell Technologies

Insulin-like growth factor 2 (IGF-II) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-II binding to IGF-I receptor activates a signaling cascade via the MAPK and PI3K pathways. IGF-II affects growth, differentiation, and survival of cells in a variety of tissues during embryonic development. It stimulates proliferation and migration of primary lymphatic endothelial cells, and induces lymphangiogenesis (Guvakova).

Supplier: Stemcell Technologies

Hamster (Armenian) monoclonal IgG2 antibody against mouse T cell receptor gamma/delta, unconjugated.

Supplier: Stemcell Technologies

Medium kit for differentiation of mouse and rat neural stem and progenitor cells.

Supplier: Stemcell Technologies

For hydrolysis of hyaluronic acid.

Supplier: Stemcell Technologies

Brain-derived neurotrophic factor (BDNF), like nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), is a member of the NGF family of neurotrophins, which are required for the differentiation and survival of specific neuronal subpopulations in both the central and the peripheral nervous systems (Minichiello and Klein; Minichiello et al.). BDNF binds with high affinity to the tropomyosin receptor kinase B (TrkB), and activates AKT and ERK pathways (Mattson et al.). It is expressed in the hippocampus, cortex, and synapses of the basal forebrain. BDNF acts as a survival factor for human embryonic stem cells when plated on either feeder cells or Corning® Matrigel® (Pyle et al.). BDNF regulates synaptic transmission and plasticity at adult synapses in the central nervous system, and contributes to adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, and homeostatic regulation of neuronal excitability (Reichardt). It also has a role in neurogenesis by promoting survival and growth of dorsal root ganglion cells, and hippocampal and cortical neurons (Binder and Scharfman). BDNF, together with glial cell line-derived neurotrophic factor (GDNF) and other supplements, is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Brafman).

Supplier: Stemcell Technologies

Mouse monoclonal antibody against human IFN-gamma, unconjugated.

Supplier: Stemcell Technologies

For purification of RNA from cells.

Supplier: Stemcell Technologies

Column-free immunomagnetic positive selection of human CD4+ cells for HLA analysis.

Supplier: Stemcell Technologies

Macrophage inflammatory protein-4 (MIP-4) plays a role in adaptive and innate immune responses, acting as a chemoattractant for T and B lymphocytes, and natural killer cells (Krohn et al.). MIP-4 can also induce immune tolerance through its effects on dendritic cells and macrophages (Azzaoui et al., Schraufstatter et al.). In breast cancer, MIP-4 has been shown to promote the invasiveness and metastasis of cancer cells in vivo by binding PITPNM3 (Chen et al.).This small cytokine belongs to the chemokine family found only in primates. Based on amino acid sequence, MIP-4 is closely related to MIP-1 alpha (CCL3) and MIP-1 beta (CCL4) (Liang et al.). MIP-4 is produced by antigen-presenting immune cells including dendritic cells, macrophages, and monocytes (Lieshout et al.). For consistency and reproducibility across your applications, macrophage inflammatory protein-4 from STEMCELL comes lyophilized with ≥95% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1.0 EU/μg protein.

Supplier: Stemcell Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee, gibbon TRA-2-49 (tissue non-specific alkaline phosphatase), unconjugated.

Supplier: Stemcell Technologies

Immunodensity isolation of untouched B cells.